Ikeda J, Kohriyama T, Maruyama H, Tanaka T, Nakamura S
3rd Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
Rinsho Shinkeigaku. 1999 Jun;39(6):625-8.
We report a 39-year-old woman with myasthenia gravis (MG) complicated by lichen planus, elevated liver enzymes of unknown cause and mucosal lesions of the colon and anus. Although the etiology of lichen planus is uncertain, an autoimmune abnormality is considered to be a possible cause. Lichen planus is sometimes associated with thymoma. This patient had hyperplasia of the thymus which was surgically removed nine years prior to lichen planus development. Myasthenic symptoms worsened when the lichen planus appeared and the liver enzymes were elevated. Steroid therapy was effective for the above symptoms. The clinical course suggests that MG, lichen planus and elevated liver enzymes in this patient results from common underlying autoimmune abnormality.
我们报告了一名39岁患有重症肌无力(MG)的女性,其并发扁平苔藓、不明原因的肝酶升高以及结肠和肛门黏膜病变。尽管扁平苔藓的病因尚不确定,但自身免疫异常被认为是可能的原因。扁平苔藓有时与胸腺瘤有关。该患者胸腺增生,在扁平苔藓出现前九年接受了胸腺手术切除。扁平苔藓出现且肝酶升高时,肌无力症状加重。类固醇治疗对上述症状有效。临床病程表明,该患者的重症肌无力、扁平苔藓和肝酶升高是由共同的潜在自身免疫异常引起的。