Dostal D E, Baker K M
Cardiovascular Research Institute, Division of Molecular Cardiology, The Texas A&M University System Health Science Center, Temple, TX 76504, USA.
Circ Res. 1999 Oct 1;85(7):643-50. doi: 10.1161/01.res.85.7.643.
Angiotensin II, the effector peptide of the renin-angiotensin system, regulates cellular growth in response to developmental, physiological, and pathological processes. The identification of renin-angiotensin system components and angiotensin II receptors in cardiac tissue suggests the existence of an autocrine/paracrine system that has effects independent of angiotensin II derived from the circulatory system. To be functional, a local renin-angiotensin system should produce sufficient amounts of the autocrine and/or paracrine factor to elicit biological responses, contain the final effector (angiotensin II receptor), and respond to humoral, neural, and/or mechanical stimuli. In this review, we discuss evidence for a functional cardiac renin-angiotensin system.
血管紧张素II是肾素-血管紧张素系统的效应肽，可响应发育、生理和病理过程调节细胞生长。心脏组织中肾素-血管紧张素系统成分和血管紧张素II受体的鉴定表明存在一种自分泌/旁分泌系统，其作用独立于循环系统衍生的血管紧张素II。要发挥功能，局部肾素-血管紧张素系统应产生足够量的自分泌和/或旁分泌因子以引发生物学反应，包含最终效应器（血管紧张素II受体），并对体液、神经和/或机械刺激作出反应。在本综述中，我们讨论了功能性心脏肾素-血管紧张素系统的证据。
