Milberger S, Faraone S V, Biederman J, Chu M P, Feighner J A
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston 02114, USA.
Am J Addict. 1999 Summer;8(3):211-9. doi: 10.1080/105504999305820.
To examine the risk for substance use disorders (SUD) in offspring of SUD parents who were not selected due to referral to SUD treatment centers.
The original sample was ascertained through two groups of index children: 140 ADHD probands and 120 non-ADHD comparison probands. These groups had 174 and 129 biological siblings and 279 and 240 parents, respectively.
We found that: 1) parental SUD was associated with SUD and all SUD subtypes in the offspring; 2) parental alcohol use disorders were associated with alcohol use disorders in the offspring as well as co-occurring alcohol and drug use disorders but not drug use disorders alone in the offspring; and 3) drug use disorders in the parents were associated with drug use disorders but not alcohol use disorders in the offspring.
These findings suggest that alcoholism and drug abuse may breed true from parents to their offspring, but further work with larger samples is needed to confirm this idea. Our findings also suggest a possible common diathesis that is expressed as comorbid alcohol and drug use in the offspring of alcoholic parents. If confirmed, these findings may be useful for the development of preventive and early intervention strategies for adolescents at high risk for SUD based on parental history of SUD.
研究未因被转介至物质使用障碍（SUD）治疗中心而入选的SUD患者的后代发生物质使用障碍的风险。
最初的样本通过两组索引儿童确定：140名注意力缺陷多动障碍（ADHD）先证者和120名非ADHD对照先证者。这些组分别有174名和129名生物学同胞以及279名和240名父母。
我们发现：1）父母的SUD与后代的SUD及所有SUD亚型相关；2）父母的酒精使用障碍与后代的酒精使用障碍以及同时发生的酒精和药物使用障碍相关，但与后代单独的药物使用障碍无关；3）父母的药物使用障碍与后代的药物使用障碍相关，但与后代的酒精使用障碍无关。
这些发现表明，酗酒和药物滥用可能会在父母与后代之间遗传，但需要对更大样本进行进一步研究以证实这一观点。我们的发现还提示存在一种可能的共同素质，表现为酗酒父母的后代同时存在酒精和药物使用问题。如果得到证实，这些发现可能有助于基于父母的SUD病史，为SUD高风险青少年制定预防和早期干预策略。
