a College of Pharmacy, Western University of Health Sciences , Pomona , CA , USA.
b Crossroads Treatment Center , Tijuana , Mexico.
J Psychoactive Drugs. 2018 Jul-Aug;50(3):256-265. doi: 10.1080/02791072.2018.1447175. Epub 2018 Apr 2.
Opioid use disorder (OUD) is currently an epidemic in the United States (US) and ibogaine is reported to have the ability to interrupt opioid addiction by simultaneously mitigating withdrawal and craving symptoms. This study examined opioid withdrawal and drug craving scores in 50 participants with OUD undergoing a week-long detoxification treatment protocol with ibogaine. The Addiction Severity Index (ASI) was used for baseline characterization of participants' OUD. Clinical Opioid Withdrawal Scale (COWS), Subjective Opioid Withdrawal Scale (SOWS), and Brief Substance Craving Scale (BSCS) scores were collected at 48 and 24 hours prior to ibogaine administration, as well as 24 and 48 hours after ibogaine administration. At 48 hours following ibogaine administration, withdrawal and craving scores were significantly lowered in comparison to baseline: 78% of patients did not exhibit objective clinical signs of opioid withdrawal, 79% reported minimal cravings for opioids, and 68% reported subjective withdrawal symptoms in the mild range. Ibogaine appears to facilitate opioid detoxification by reducing opioid withdrawal and craving in participants with OUD. These results warrant further research using rigorous controlled trials.
阿片类使用障碍（OUD）目前在美国（美国）是一种流行疾病，据报道伊博加因具有通过同时减轻戒断和渴望症状来中断阿片类成瘾的能力。这项研究检查了 50 名患有 OUD 的参与者在接受伊博加因进行为期一周的戒毒治疗方案期间的阿片类戒断和药物渴望评分。成瘾严重程度指数（ASI）用于对参与者 OUD 的基线特征进行描述。在给予伊博加因之前的 48 小时和 24 小时，以及给予伊博加因之后的 24 小时和 48 小时，收集临床阿片类戒断量表（COWS）、主观阿片类戒断量表（SOWS）和简短物质渴求量表（BSCS）评分。在给予伊博加因 48 小时后，与基线相比，戒断和渴望评分显著降低：78%的患者没有表现出阿片类药物戒断的客观临床迹象，79%报告对阿片类药物的渴望最小，68%报告主观戒断症状处于轻度范围。伊博加因似乎通过减少 OUD 参与者的阿片类戒断和渴望来促进阿片类药物的解毒。这些结果需要进一步使用严格的对照试验进行研究。
