Labbé A C, Bourgault A M, Vincelette J, Turgeon P L, Lamothe F
Département de Microbiologie Médicale et Infectiologie, Centre Hospitalier de l'Université de Montréal, Montréal, Canada.
Antimicrob Agents Chemother. 1999 Oct;43(10):2517-9. doi: 10.1128/AAC.43.10.2517.
The objective of the present study was to analyze the susceptibility profiles of 911 clinical strains of the Bacteroides fragilis group isolated from 1992 to 1997 in our institution in order to monitor susceptibility changes over time. Whereas the rates of resistance to metronidazole, imipenem, piperacillin-tazobactam, ticarcillin-clavulanic acid, penicillin, piperacillin, and cefoxitin remained essentially unchanged, there was a significant increase in the rates of resistance to clindamycin, which rose from 8.2% in 1992 to 19.7% in 1997 (P < 0.0004).
本研究的目的是分析1992年至1997年期间从我们机构分离出的911株脆弱拟杆菌属临床菌株的药敏谱，以监测随时间的药敏变化。虽然对甲硝唑、亚胺培南、哌拉西林-他唑巴坦、替卡西林-克拉维酸、青霉素、哌拉西林和头孢西丁的耐药率基本保持不变，但对克林霉素的耐药率显著增加，从1992年的8.2%升至1997年的19.7%（P<0.0004）。
