Sammut B, Du Pasquier L, Ducoroy P, Laurens V, Marcuz A, Tournefier A
Basel Institute for Immunology Basel, Switzerland.
Eur J Immunol. 1999 Sep;29(9):2897-907. doi: 10.1002/(SICI)1521-4141(199909)29:09<2897::AID-IMMU2897>3.0.CO;2-2.
The MHC of the urodele amphibian Ambystoma mexicanum consists of multiple polymorphic class I loci linked, so far as yet known, to a single class II B locus. This architecture is very different from that of the anuran amphibian Xenopus. The number of class I loci in the axolotl can vary from 6 to 21 according to the haplotypes as shown by cDNA analysis and Southern blot studies in families. These loci can be classified into seven sequence groups with features ranging from the class Ia to the class Ib type. All individuals express genes from at least three of the seven groups, and all individuals possess the class Ia-like type.
美西钝口螈这种有尾两栖动物的主要组织相容性复合体（MHC）由多个多态性的I类基因座组成，就目前所知，这些基因座与单个II类B基因座相连。这种结构与无尾两栖动物非洲爪蟾的结构非常不同。根据家族中的cDNA分析和Southern印迹研究显示，美西钝口螈中I类基因座的数量根据单倍型不同，从6个到21个不等。这些基因座可分为七个序列组，其特征从Ia类到Ib类。所有个体至少表达七个组中三个组的基因，并且所有个体都拥有类Ia样类型。
