Provost E, Rimm D L
Department of Pathology Yale University School of Medicine 310 Cedar Street, New Haven, CT 06510, USA.
Curr Opin Cell Biol. 1999 Oct;11(5):567-72. doi: 10.1016/s0955-0674(99)00015-0.
Cadherin-mediated cell-cell interactions are modulated by protein interactions at the cytoplasmic face of the membrane. Recent work has shown that phosphorylation of both p120(ctn) and beta-catenin affects their interaction with cadherins and the molecular connections to the cytoskeleton. The cytoskeletal connections most probably include interactions between alpha-catenin, and/or alpha-actinin, vinculin, ZO-1, actin and possibly spectrin.
钙黏蛋白介导的细胞间相互作用受膜细胞质面蛋白质相互作用的调节。最近的研究表明，p120（连环蛋白）和β-连环蛋白的磷酸化都会影响它们与钙黏蛋白的相互作用以及与细胞骨架的分子连接。细胞骨架连接很可能包括α-连环蛋白、和/或α-辅肌动蛋白、纽蛋白、闭锁蛋白、肌动蛋白以及可能的血影蛋白之间的相互作用。
