Kusumi A, Suzuki K, Koyasako K
Department of Biological Science Graduate School of Science Nagoya University Chikusa-ku, 464-8602, Kusumi Membrane Organizer Project ERATO, JST Kumazaki Building, Chiyoda 5-11-33, Nagoya, 460-0012, Japan.
Curr Opin Cell Biol. 1999 Oct;11(5):582-90. doi: 10.1016/s0955-0674(99)00020-4.
Clustering of cell adhesion receptors and their interactions with the cytoskeleton are key events in the formation and function of cell adhesion structures. On the free cell surface, cadherin molecules interact with the cytoskeleton/membrane skeleton by being bound or corralled, and such interactions are greatly enhanced by the formation of cadherin oligomers. Corralled cadherin molecules undergo hop diffusion from one compartment to an adjacent one (membrane skeleton fence model), which prompts the initial formation of small adhesion clusters at cell-cell contact sites, but larger-scale assemblies of cadherin and actin filaments might require a further co-ordinated recruitment of these molecules.
细胞黏附受体的聚集及其与细胞骨架的相互作用是细胞黏附结构形成和功能中的关键事件。在游离的细胞表面，钙黏蛋白分子通过被结合或被限制而与细胞骨架/膜骨架相互作用，并且钙黏蛋白寡聚体的形成极大地增强了这种相互作用。被限制的钙黏蛋白分子从一个区室向相邻区室进行跳跃扩散（膜骨架围栏模型），这促使在细胞 - 细胞接触位点最初形成小的黏附簇，但钙黏蛋白和肌动蛋白丝的更大规模组装可能需要这些分子的进一步协同募集。
