Henry M D, Campbell K P
Howard Hughes Medical Institute Department of Physiology and Biophysics Department of Neurology University of Iowa College of Medicine 400 Eckstein Medical Research Building, Iowa City, IA 52242, USA.
Curr Opin Cell Biol. 1999 Oct;11(5):602-7. doi: 10.1016/s0955-0674(99)00024-1.
Dystroglycan connects the extracellular matrix and cytoskeleton. Key findings in the past year indicate that dystroglycan interacts with a wider repertoire of extracellular ligands than originally appreciated, that dystroglycan plays a critical role in organizing extracellular matrix molecules on the cell surface and in basement membranes, and that at least two human pathogens utilize dystroglycan to gain access to host cells. Together, these advances begin to help elucidate important biological roles for dystroglycan in development and disease.
肌营养不良聚糖连接细胞外基质和细胞骨架。过去一年的关键研究结果表明，肌营养不良聚糖与比最初认为的更广泛的细胞外配体相互作用，肌营养不良聚糖在细胞表面和基底膜上组织细胞外基质分子方面发挥关键作用，并且至少两种人类病原体利用肌营养不良聚糖进入宿主细胞。这些进展共同开始有助于阐明肌营养不良聚糖在发育和疾病中的重要生物学作用。
