Lee S J, McPherron A C
Department of Molecular Biology and Genetics Johns Hopkins University School of Medicine 725 North Wolfe Street, Baltimore, Maryland, 21205, USA.
Curr Opin Genet Dev. 1999 Oct;9(5):604-7. doi: 10.1016/s0959-437x(99)00004-0.
The mechanisms by which tissue size is controlled are poorly understood. Over 30 years ago, Bullough proposed the existence of chalones, which act as tissue-specific negative growth regulators. The recent discovery of myostatin suggests that negative regulation of tissue growth may be an important mechanism for controlling skeletal muscle mass and raises the possibility that growth inhibitors may also be involved in regulating the size of other tissues.
目前对控制组织大小的机制了解甚少。30多年前，布洛提出了抑素的存在，它作为组织特异性的负生长调节因子。最近发现的肌肉生长抑制素表明，组织生长的负调节可能是控制骨骼肌质量的重要机制，并增加了生长抑制剂也可能参与调节其他组织大小的可能性。
