左旋咪唑治疗复发性口疮的双盲研究。

Double-blind study of levamisole in aphthous stomatitis.

作者信息

Kaplan B, Cardarelli C, Pinnell S R

出版信息

J Oral Pathol. 1978;7(6):400-4. doi: 10.1111/j.1600-0714.1978.tb01609.x.

DOI:10.1111/j.1600-0714.1978.tb01609.x

Abstract

Sixty-five patients with recurrent aphthous stomatitis participated in a double-blind study to evaluate levamisole. Nineteen of 34 patients improved on levamisole and only five of 31 patients improved on placebo (P less than 0.004, chi-square with two degrees of freedom). After breaking the code and switching placebo patients to levamisole and non-responders to an alternate dosage schedule, 46 of 60 patients noted clinical improvement.

摘要

65例复发性口疮性口炎患者参与了一项评估左旋咪唑的双盲研究。34例使用左旋咪唑的患者中有19例病情改善，而31例使用安慰剂的患者中只有5例病情改善（自由度为2的卡方检验，P<0.004）。在破盲并将使用安慰剂的患者换用左旋咪唑以及将无反应者换用另一种给药方案后，60例患者中有46例临床症状改善。