对影响黑腹果蝇3号染色体上翅膀形状的多基因的分析。
An analysis of polygenes affecting wing shape on chromosome 3 in Drosophila melanogaster.
作者信息
Weber K, Eisman R, Morey L, Patty A, Sparks J, Tausek M, Zeng Z B
机构信息
Department of Biological Sciences, University of Southern Maine, Portland, Maine 04104-9300, USA.
出版信息
Genetics. 1999 Oct;153(2):773-86. doi: 10.1093/genetics/153.2.773.
Abstract
Loci on the third chromosome of Drosophila melanogaster that affect an index of wing shape were mapped, using recombinant isogenic lines, with transposable elements as markers. Many genes with small subequal effects are dispersed along the whole chromosome. Their alleles act nearly additively in heterozygotes. They have small correlated effects on leg shape, but no detectable effects on halteres. Small negative net interactions occur over most of the chromosome. The data set of 519 recombinant isogenic lines can be explained reasonably well by two models. One model posits an indefinitely large number of loci with no interactions. The other model posits 11 loci with additive effects whose sum equals the total phenotypic range and with large positive and negative interactions that nearly cancel each other.
摘要
利用重组近交系，并以转座元件作为标记，对影响果蝇翅形指数的位于第三条染色体上的基因座进行了定位。许多具有微小且近乎相等效应的基因分散在整条染色体上。它们的等位基因在杂合子中表现出近乎累加的作用。它们对腿形有微小的相关效应，但对平衡棒没有可检测到的影响。在染色体的大部分区域都存在微小的负向净相互作用。由519个重组近交系组成的数据集可以用两种模型较好地解释。一种模型假设有无限多个没有相互作用的基因座。另一种模型假设有11个具有累加效应的基因座，其效应总和等于总表型范围，并且具有几乎相互抵消的大的正向和负向相互作用。
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