数量性状定位的经验阈值
Empirical threshold values for quantitative trait mapping.
作者信息
Churchill G A, Doerge R W
机构信息
Biometrics Unit, Cornell University, Ithaca, New York 14853.
出版信息
Genetics. 1994 Nov;138(3):963-71. doi: 10.1093/genetics/138.3.963.
Abstract
The detection of genes that control quantitative characters is a problem of great interest to the genetic mapping community. Methods for locating these quantitative trait loci (QTL) relative to maps of genetic markers are now widely used. This paper addresses an issue common to all QTL mapping methods, that of determining an appropriate threshold value for declaring significant QTL effects. An empirical method is described, based on the concept of a permutation test, for estimating threshold values that are tailored to the experimental data at hand. The method is demonstrated using two real data sets derived from F(2) and recombinant inbred plant populations. An example using simulated data from a backcross design illustrates the effect of marker density on threshold values.
摘要
检测控制数量性状的基因是遗传图谱学界极为感兴趣的一个问题。相对于遗传标记图谱定位这些数量性状基因座（QTL）的方法目前已被广泛应用。本文探讨了所有QTL定位方法共同面临的一个问题，即确定用于宣告显著QTL效应的合适阈值。描述了一种基于置换检验概念的经验方法，用于估计适合手头实验数据的阈值。使用从F(2)和重组自交植物群体得到的两个真实数据集对该方法进行了演示。一个使用回交设计模拟数据的例子说明了标记密度对阈值的影响。
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