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酸脂肪细胞比容在儿科临床实践中的应用价值

Clinical usefulness of acid steatocrit in pediatric practice.

作者信息

Catapani W R, da Silva A N, de Morais M B, Fagundes Neto U

机构信息

Division of Pediatric Gastroenterology, Federal University of São Paulo (UNIFESP), Brazil.

出版信息

Arq Gastroenterol. 1999 Apr-Jun;36(2):105-8.

Abstract

The steatocrit technique has been frequently used in the follow up of malabsorption syndromes. The classical steatocrit method has recently been improved by adding perchloric acid to the fecal homogenate (acid steatocrit), this technique showed a better correlation with fecal fat concentration than the classical test. In our protocol, we aimed at an assessment of the clinical usefulness of the acid steatocrit when compared to the traditional technique. Children who were referred to the laboratory for evaluation of steatorrhea were studied by the fecal fat balance, which was taken as a gold standard method for the comparison between both steatocrits. The method was slightly modified, by using hydrochloric instead of perchloric acid. Our results showed a sensitivity of 88.8% for the acid steatocrit and 66.7% for the classical method, at a 1.6% cut off value. We suggest the method as useful to rule out steatorrhea, thus selecting those children who should not be submitted to more laborious and time consuming methods such as the fecal fat balance.

摘要

脂肪细胞比容技术常用于吸收不良综合征的随访。经典的脂肪细胞比容方法最近通过向粪便匀浆中添加高氯酸(酸脂肪细胞比容)得到了改进,该技术与粪便脂肪浓度的相关性比经典检测方法更好。在我们的方案中,我们旨在评估与传统技术相比酸脂肪细胞比容的临床实用性。因脂肪泻转诊至实验室评估的儿童通过粪便脂肪平衡进行研究,粪便脂肪平衡被用作两种脂肪细胞比容比较的金标准方法。该方法略有修改,使用盐酸代替高氯酸。我们的结果显示,在1.6%的临界值时,酸脂肪细胞比容的敏感性为88.8%,经典方法为66.7%。我们认为该方法有助于排除脂肪泻,从而筛选出那些不应接受更费力、耗时的方法(如粪便脂肪平衡)的儿童。

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