Sacco A G
Department of Obstetrics and Gynecology, C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, Michigan 48201.
Am J Reprod Immunol Microbiol. 1987 Dec;15(4):122-30.
The porcine zona pellucida represents a unique immunocontraceptive target antigen. Initial active immunization studies using crude or partially purified zona components as immunogens resulted in adverse, nonreversible effects on ovarian folliculogenesis, but more recent findings in nonhuman primates indicate that such effects are not as severe and are reversible. Consequently, current efforts are directed toward identifying a zona immunogen that elicits contraceptive antibodies that produce no adverse effects on the ovary. Other studies are in progress to determine optimal injection/immunization format, proper immunogen dosage, and appropriate adjuvant for use in the zona-antizona immunocontraceptive system. Recent data have been very encouraging and emphasize the contraceptive efficacy of this approach to reproduction control.
猪透明带是一种独特的免疫避孕靶抗原。最初使用粗制或部分纯化的透明带成分作为免疫原进行的主动免疫研究，对卵巢卵泡发生产生了不良的、不可逆的影响，但最近在非人类灵长类动物中的研究结果表明，这些影响并不那么严重，而且是可逆的。因此，目前的工作方向是确定一种能引发避孕抗体且对卵巢无不良影响的透明带免疫原。其他研究正在进行中，以确定在透明带 - 抗透明带免疫避孕系统中使用的最佳注射/免疫方式、合适的免疫原剂量和适当的佐剂。最近的数据非常令人鼓舞，并强调了这种生殖控制方法的避孕效果。
