二硫代氨基甲酸盐作为潜在新型抗锥虫药物的应用：方法化学、功能和生物学研究。
Application of Dithiocarbamates as Potential New Antitrypanosomatids-Drugs: Approach Chemistry, Functional and Biological.
机构信息
Laboratório de Imunoparasitologia, Departamento de Análises Clínicas e Toxicológicas, Centro de Ciências da Saúde, Universidade Federal do Rio Grande do Norte, Natal 59012-570, Brazil.
Programa de Pós-graduação em Bioquímica, Centro de Biociências, Universidade Federal do Rio Grande do Norte, Natal 59012-570, Brazil.
出版信息
Molecules. 2019 Aug 1;24(15):2806. doi: 10.3390/molecules24152806.
Dithiocarbamates represent a class of compounds that were evaluated in different biomedical applications because of their chemical versatility. For this reason, several pharmacological activities have already been attributed to these compounds, such as antiparasitic, antiviral, antifungal activities, among others. Therefore, compounds that are based on dithiocarbamates have been evaluated in different in vivo and in vitro models as potential new antimicrobials. Thus, the purpose of this review is to present the possibilities of using dithiocarbamate compounds as potential new antitrypanosomatids-drugs, which could be used for the pharmacological control of Chagas disease, leishmaniasis, and African trypanosomiasis.
二硫代氨基甲酸盐类化合物是一类具有广泛应用前景的化合物，因为它们具有化学多样性。因此，已经有许多药理学活性被归因于这些化合物，如抗寄生虫、抗病毒、抗真菌等。因此，基于二硫代氨基甲酸盐的化合物已经在不同的体内和体外模型中被评估为潜在的新型抗菌药物。因此，本综述的目的是介绍将二硫代氨基甲酸盐化合物用作潜在的新型抗锥虫药物的可能性，这些药物可用于治疗恰加斯病、利什曼病和非洲锥虫病的药理学控制。
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