新型烷基连接的双（2-硫代-[1,3,5]噻二嗪烷-3-基）羧酸的合成与抗原生动物活性评估
Synthesis and antiprotozoan evaluation of new alkyl-linked bis(2-thioxo-[1,3,5]thiadiazinan-3-yl) carboxylic acids.
作者信息
Coro Julieta, Pérez Rolando, Rodríguez Hortensia, Suárez Margarita, Vega Celeste, Rolón Miriam, Montero David, Nogal Juan José, Gómez-Barrio Alicia
机构信息
Laboratorio de Síntesis Orgánica, Facultad de Química, Universidad de la Habana, 10400-Ciudad Habana, Cuba.
出版信息
Bioorg Med Chem. 2005 May 16;13(10):3413-21. doi: 10.1016/j.bmc.2005.03.009.
Two new series of several alkyl-linked bis(2-thioxo-[1,3,5]thiadiazinan-3-yl) carboxylic acids were synthesized in a two step procedure from the corresponding alkyl bis-dithiocarbamic salt intermediary. The novel compounds were evaluated for their activity in vitro against Trypanosoma cruzi strain CL (clone CL B5) and Trichomonas vaginalis strain JH 31A.
通过两步法从相应的烷基双二硫代氨基甲酸盐中间体合成了两个新系列的几种烷基连接的双(2-硫代-[1,3,5]噻二嗪-3-基)羧酸。对这些新化合物进行了体外抗克氏锥虫CL株(克隆CL B5)和阴道毛滴虫JH 31A株活性的评估。
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