三个不同基因的等位基因之间的优先关联表明人类疱疹病毒7存在两种原型变体。
Preferential associations of alleles of three distinct genes argue for the existence of two prototype variants of human herpesvirus 7.
作者信息
Franti M, Aubin J T, Gautheret-Dejean A, Malet I, Cahour A, Huraux J M, Agut H
机构信息
Laboratoire de Virologie, C.E.R.V.I., UPRES EA 2387, Hôpital Pitié-Salpétrière, 75651 Paris Cedex 13, France.
出版信息
J Virol. 1999 Nov;73(11):9655-8. doi: 10.1128/JVI.73.11.9655-9658.1999.
We had previously described six distinct alleles of the glycoprotein B (gB) gene of human herpesvirus 7 (HHV-7). The genetic changes corresponding to these alleles did not affect gB gene transcription or translation in in vitro assays. The study of distinct HHV-7-positive human samples showed preferential associations of some gB alleles with some alleles of two other genes, distantly located on the HHV-7 genome, coding for the phosphoprotein p100 (p100) and the major capsid protein (MCP). Two allele combinations, corresponding to 44 and 31% of the samples studied, respectively, were interpreted as the genetic signatures of two major prototype HHV-7 variants.
我们之前曾描述过人疱疹病毒7型（HHV - 7）糖蛋白B（gB）基因的六个不同等位基因。在体外试验中，与这些等位基因相对应的基因变化并不影响gB基因的转录或翻译。对不同的HHV - 7阳性人类样本进行研究发现，某些gB等位基因与HHV - 7基因组上距离较远的另外两个基因的某些等位基因存在优先关联，这两个基因分别编码磷蛋白p100（p100）和主要衣壳蛋白（MCP）。分别对应于所研究样本的44%和31%的两种等位基因组合，被解释为两种主要HHV - 7原型变体的基因特征。
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