Exploring the dynamics of regulation of G protein-coupled receptors using green fluorescent protein.
作者信息
Milligan G
机构信息
Molecular Pharmacology Group, Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow.
出版信息
Br J Pharmacol. 1999 Oct;128(3):501-10. doi: 10.1038/sj.bjp.0702824.
Abstract
摘要
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Quantification of G-Protein Coupled Receptor Internatilization Using G-Protein Coupled Receptor-Green Fluorescent Protein Conjugates with the ArrayScantrade mark High-Content Screening System.使用带有ArrayScan商标高内涵筛选系统的G蛋白偶联受体-绿色荧光蛋白缀合物对G蛋白偶联受体内化进行定量分析。
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Visualization of agonist-induced association and trafficking of green fluorescent protein-tagged forms of both beta-arrestin-1 and the thyrotropin-releasing hormone receptor-1.可视化激动剂诱导的β-抑制蛋白1和促甲状腺激素释放激素受体1的绿色荧光蛋白标记形式的结合与转运。
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Trafficking of proteinase-activated receptor-2 and beta-arrestin-1 tagged with green fluorescent protein. beta-Arrestin-dependent endocytosis of a proteinase receptor.绿色荧光蛋白标记的蛋白酶激活受体-2和β-抑制蛋白-1的转运。蛋白酶受体的β-抑制蛋白依赖性内吞作用。
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Cellular trafficking of G protein-coupled receptor/beta-arrestin endocytic complexes.G蛋白偶联受体/β-抑制蛋白内吞复合物的细胞转运
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10
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