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成年灵长类动物新皮层中的神经发生

Neurogenesis in the neocortex of adult primates.

作者信息

Gould E, Reeves A J, Graziano M S, Gross C G

机构信息

Department of Psychology, Princeton University, Princeton, NJ 08544, USA.

出版信息

Science. 1999 Oct 15;286(5439):548-52. doi: 10.1126/science.286.5439.548.

DOI:10.1126/science.286.5439.548
PMID:10521353
Abstract

In primates, prefrontal, inferior temporal, and posterior parietal cortex are important for cognitive function. It is shown that in adult macaques, new neurons are added to these three neocortical association areas, but not to a primary sensory area (striate cortex). The new neurons appeared to originate in the subventricular zone and to migrate through the white matter to the neocortex, where they extended axons. These new neurons, which are continually added in adulthood, may play a role in the functions of association neocortex.

摘要

在灵长类动物中,前额叶、颞下叶和顶叶后皮质对认知功能很重要。研究表明,在成年猕猴中,这三个新皮质联合区会添加新的神经元,但初级感觉区(纹状皮质)则不会。新神经元似乎起源于脑室下区,并通过白质迁移至新皮质,在那里它们会延伸轴突。这些在成年期持续添加的新神经元可能在联合新皮质的功能中发挥作用。

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