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静脉注射己酮可可碱(“曲克芦丁”)后脑血流量的测量。

Measurement of cerebral blood flow following intravenous administration of pentoxifyline ('Trentral').

作者信息

Koppenhagen K, Wenig H G, Müller K

出版信息

Curr Med Res Opin. 1977;4(7):521-8. doi: 10.1185/03007997709109343.

DOI:10.1185/03007997709109343
PMID:844329
Abstract

Using 99mTc cerebral scintigraphy and a gamma camera/computer system, the pattern of cerebral blood flow in 5 brain areas was monitored in 30 geriatric patients with cerebrovascular insufficiency. Readings were compared on a within-patient basis for the following treatments: initial control (I), intravenous administration of 10 ml physiological saline solution (II), and intravenous administration of 10 ml (200 mg) pentoxifylline (III). By comparsion with treatment I and II, pentoxifylline produced significant increases in cerebral blood flow. It is suggested that this increase in perfusion is possibly due to an improvement in the flow properties of blood.

摘要

使用99mTc脑闪烁扫描术和γ相机/计算机系统,对30例患有脑血管功能不全的老年患者5个脑区的脑血流模式进行了监测。在患者自身基础上对以下治疗的读数进行了比较:初始对照(I)、静脉注射10毫升生理盐水溶液(II)以及静脉注射10毫升(200毫克)己酮可可碱(III)。与治疗I和II相比,己酮可可碱使脑血流量显著增加。提示这种灌注增加可能是由于血液流动特性的改善。

相似文献

1
Measurement of cerebral blood flow following intravenous administration of pentoxifyline ('Trentral').静脉注射己酮可可碱(“曲克芦丁”)后脑血流量的测量。
Curr Med Res Opin. 1977;4(7):521-8. doi: 10.1185/03007997709109343.
2
The effect of pentoxifylline ('Trental') on cerebral blood flow: a double-blind study.己酮可可碱(“曲克芦丁”)对脑血流量的影响:一项双盲研究。
Curr Med Res Opin. 1976;4(10):681-7. doi: 10.1185/03007997609112002.
3
Effect of pentoxifylline on cerebral blood flow in patients with chronic cerebrovascular disease.己酮可可碱对慢性脑血管病患者脑血流量的影响。
J Int Med Res. 1981;9(3):211-4. doi: 10.1177/030006058100900311.
4
Effect of pentoxifylline on regional cerebral blood flow in patients with cerebrovascular disease.己酮可可碱对脑血管疾病患者局部脑血流的影响。
Pharmatherapeutica. 1981;2(8):528-31.
5
Pentoxifylline increases cerebral blood flow in patients with cerebrovascular disease.己酮可可碱可增加脑血管疾病患者的脑血流量。
Stroke. 1989 Dec;20(12):1662-6. doi: 10.1161/01.str.20.12.1662.
6
Haemorheology and cerebrovascular disease: multifunctional approach with pentoxifylline.
Curr Med Res Opin. 1981;7(4):253-63. doi: 10.1185/03007998109114271.
7
Comparative randomized study of cerebral blood flow after long-term administration of pentoxifylline and co-dergocrine mesylate in patients with chronic cerebrovascular disease.
Curr Med Res Opin. 1985;9(7):475-9. doi: 10.1185/03007998509109621.
8
Clinical evaluation of the effect of pentoxifylline on circulatory behavior of the brain.己酮可可碱对脑循环行为影响的临床评估。
Kurume Med J. 1979;26(4):331-4. doi: 10.2739/kurumemedj.26.331.
9
Effect of oxpentifylline on blood viscosity and cerebral blood flow in man.己酮可可碱对人体血液粘度和脑血流量的影响。
Br J Clin Pharmacol. 1989 Oct;28(4):488-92. doi: 10.1111/j.1365-2125.1989.tb03531.x.
10
Cerebral blood flow under hypobaric conditions: effects of pentoxifylline ('Trental' 400).低压条件下的脑血流量:己酮可可碱(“曲克芦丁”400)的作用
Pharmatherapeutica. 1984;4(1):1-5.

引用本文的文献

1
Pentoxifylline (oxpentifylline). A review of its therapeutic efficacy in the management of peripheral vascular and cerebrovascular disorders.己酮可可碱(氧代己酮可可碱)。对其治疗外周血管疾病和脑血管疾病疗效的综述。
Drugs Aging. 1995 Dec;7(6):480-503. doi: 10.2165/00002512-199507060-00007.
2
Pentoxifylline. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy.己酮可可碱。对其药效学和药代动力学特性以及治疗效果的综述。
Drugs. 1987 Jul;34(1):50-97. doi: 10.2165/00003495-198734010-00003.
3
Effect of oxpentifylline on blood viscosity and cerebral blood flow in man.
己酮可可碱对人体血液粘度和脑血流量的影响。
Br J Clin Pharmacol. 1989 Oct;28(4):488-92. doi: 10.1111/j.1365-2125.1989.tb03531.x.