Bhattacharya A, Chatterjee A, Ghosal S, Bhattacharya S K
Department of Chemistry, Bose Institute, Calcutta, India.
Indian J Exp Biol. 1999 Jul;37(7):676-80.
The antioxidant activity of tannoid active principles of E. officinalis consisting of emblicanin A (37%), emblicanin B (33%), punigluconin (12%) and pedunculagin (14%), was investigated on the basis of their effects on rat brain frontal cortical and striatal concentrations of the oxidative free radical scavenging enzymes, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX), and lipid peroxidation, in terms of thiobarbituric acid-reactive products. The results were compared with effects induced by deprenyl, a selective monoamine oxidase (MAO) B inhibitor with well documented antioxidant activity. The active tannoids of E. officinalis (EOT), administered in the doses of 5 and 10 mg/kg, i.p., and deprenyl (2 mg/kg, i.p.), induced an increase in both frontal cortical and striatal SOD, CAT and GPX activity, with concomitant decrease in lipid peroxidation in these brain areas when administered once daily for 7 days. Acute single administration of EOT and deprenyl had insignificant effects. The results also indicate that the antioxidant activity of E. officinalis may reside in the tannoids of the fruits of the plant, which have vitamin C-like properties, rather than vitamin C itself.
基于余甘子中鞣质活性成分（包括恩波苷A（37%）、恩波苷B（33%）、诃子次酸（12%）和诃子鞣质（14%））对大鼠脑额叶皮质和纹状体中氧化自由基清除酶超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GPX）浓度以及脂质过氧化（以硫代巴比妥酸反应产物衡量）的影响，对其抗氧化活性进行了研究。将结果与司来吉兰（一种具有充分文献记载抗氧化活性的选择性单胺氧化酶（MAO）B抑制剂）所诱导的效应进行了比较。余甘子活性鞣质（EOT）以5和10 mg/kg的剂量腹腔注射，司来吉兰以2 mg/kg的剂量腹腔注射，连续7天每日给药一次，均可使额叶皮质和纹状体中的SOD、CAT和GPX活性增加，同时这些脑区的脂质过氧化减少。急性单次给予EOT和司来吉兰的影响不显著。结果还表明，余甘子的抗氧化活性可能存在于该植物果实的鞣质中，这些鞣质具有类似维生素C的特性，而非维生素C本身。
