Nakai J S, Stathopulos P B, Campbell G L, Chu I, Li-Muller A, Aucoin R
Health Canada, Bureau of Chemical Hazards, Ottawa, Ontario.
J Toxicol Environ Health A. 1999 Oct 15;58(3):157-70. doi: 10.1080/009841099157368.
In vitro dermal absorption was measured for three volatile organic compounds in dilute aqueous solution through freshly prepared and previously frozen human skin. The permeability coefficients at 26 degrees C for chloroform (0.14 cm/h) and trichloroethylene (0.12 cm/h) were similar but much larger than that for tetrachloroethylene (0.018 cm/h). Storage of the skin at -20 degrees C did not significantly affect the penetration of these chemicals. The dermal absorption of chloroform through freshly prepared human skin was not changed significantly by pretreatment of the skin with commonly used consumer products (moisturizer, baby oil, insect repellent, sunscreen); however, the permeability coefficient was found to increase from 0.071 cm/h at 11 degrees C to 0.19 cm/h at 50 degrees C. These data suggest that exposure estimates for chloroform and other contaminants in water should consider the appropriate exposure scenario to properly assess the dermal dose.
通过新鲜制备的和预先冷冻的人体皮肤，测定了三种挥发性有机化合物在稀水溶液中的体外皮肤吸收情况。26℃时，氯仿（0.14 cm/h）和三氯乙烯（0.12 cm/h）的渗透系数相似，但远大于四氯乙烯（0.018 cm/h）的渗透系数。皮肤在-20℃下储存对这些化学物质的渗透没有显著影响。通过新鲜制备的人体皮肤对氯仿的皮肤吸收，在使用常用消费品（保湿霜、婴儿油、驱虫剂、防晒霜）对皮肤进行预处理后没有显著变化；然而，发现渗透系数从11℃时的0.071 cm/h增加到50℃时的0.19 cm/h。这些数据表明，对于水中氯仿和其他污染物的暴露估计，应考虑适当的暴露场景，以正确评估皮肤剂量。
