唾液碳酸酐酶同工酶VI
Salivary carbonic anhydrase isoenzyme VI.
作者信息
Kivela J, Parkkila S, Parkkila A K, Leinonen J, Rajaniemi H
机构信息
Department of Anatomy and Cell Biology, University of Oulu, Oulu, Parolannummi Garrison Hospital, Finnish Defence Forces, Hattula.
出版信息
J Physiol. 1999 Oct 15;520 Pt 2(Pt 2):315-20. doi: 10.1111/j.1469-7793.1999.t01-1-00315.x.
Abstract
The carbonic anhydrases (CAs) participate in the maintenance of pH homeostasis in various tissues and biological fluids of the human body by catalysing the reversible reaction CO2 + H2O HCO3- + H+ (Davenport & Fisher, 1938; Davenport, 1939; Maren, 1967). Carbonic anhydrase isoenzyme VI (CA VI) is the only secretory isoenzyme of the mammalian CA gene family. It is exclusively expressed in the serous acinar cells of the parotid and submandibular glands, from where it is secreted into the saliva. In this review, we will discuss recent advances in research focused on the physiological role of salivary CA VI in the oral cavity and upper alimentary canal.
摘要
碳酸酐酶（CAs）通过催化可逆反应CO2 + H2O⇌HCO3- + H+，参与维持人体各种组织和生物体液中的pH稳态（达文波特和费舍尔，1938年；达文波特，1939年；马伦，1967年）。碳酸酐酶同工酶VI（CA VI）是哺乳动物CA基因家族唯一的分泌型同工酶。它仅在腮腺和颌下腺的浆液性腺泡细胞中表达，并从那里分泌到唾液中。在这篇综述中，我们将讨论聚焦于唾液CA VI在口腔和上消化道生理作用的研究最新进展。
相似文献
1
Salivary carbonic anhydrase isoenzyme VI.唾液碳酸酐酶同工酶VI
J Physiol. 1999 Oct 15;520 Pt 2(Pt 2):315-20. doi: 10.1111/j.1469-7793.1999.t01-1-00315.x.
2
A low concentration of carbonic anhydrase isoenzyme VI in whole saliva is associated with caries prevalence.全唾液中低浓度的碳酸酐酶同工酶VI与龋齿患病率相关。
Caries Res. 1999 May-Jun;33(3):178-84. doi: 10.1159/000016514.
3
Immunohistochemical localization of carbonic anhydrase isoenzymes VI, II, and I in human parotid and submandibular glands.碳酸酐酶同工酶VI、II和I在人腮腺和颌下腺中的免疫组织化学定位。
J Histochem Cytochem. 1990 Jul;38(7):941-7. doi: 10.1177/38.7.2113069.
4
Carbonic anhydrase in mouse salivary glands and saliva: a histochemical, immunohistochemical, and enzyme activity study.小鼠唾液腺和唾液中的碳酸酐酶：一项组织化学、免疫组织化学及酶活性研究。
J Histochem Cytochem. 1984 Jun;32(6):625-35. doi: 10.1177/32.6.6427328.
5
Distribution of the carbonic anhydrase isoenzymes I, II, and VI in the human alimentary tract.碳酸酐酶同工酶I、II和VI在人体消化道中的分布。
Gut. 1994 May;35(5):646-50. doi: 10.1136/gut.35.5.646.
6
Radioimmunoassay of carbonic anhydrase VI in saliva and sheep tissues.唾液和绵羊组织中碳酸酐酶VI的放射免疫测定
Biochem J. 1991 Mar 1;274 ( Pt 2)(Pt 2):313-6. doi: 10.1042/bj2740313.
7
A role of salivary carbonic anhydrase VI in dental plaque.唾液碳酸酐酶VI在牙菌斑中的作用。
Arch Oral Biol. 2006 Feb;51(2):117-22. doi: 10.1016/j.archoralbio.2005.04.007. Epub 2005 Jun 14.
8
Redistribution of carbonic anhydrase VI expression from ducts to acini during development of ovine parotid and submandibular glands.
Histochem Cell Biol. 1997 May;107(5):417-22. doi: 10.1007/s004180050128.
9
Radioimmunoassay for salivary carbonic anhydrase in human parotid saliva.人腮腺唾液中唾液碳酸酐酶的放射免疫测定
Arch Oral Biol. 1995 Jun;40(6):567-9. doi: 10.1016/0003-9969(95)00001-6.
10
Immunohistolocalization and gene expression of the secretory carbonic anhydrase isozymes (CA-VI) in canine oral mucosa, salivary glands and oesophagus.犬口腔黏膜、唾液腺和食管中分泌性碳酸酐酶同工酶（CA-VI）的免疫组织定位及基因表达
Anat Histol Embryol. 2007 Feb;36(1):53-7. doi: 10.1111/j.1439-0264.2006.00721.x.
引用本文的文献
1
Modulation of test anxiety-induced salivary protein secretion by ovarian steroid hormones: a preliminary study.卵巢甾体激素对考试焦虑诱导的唾液蛋白质分泌的调节作用：一项初步研究。
J Physiol Biochem. 2025 Feb;81(1):215-228. doi: 10.1007/s13105-025-01067-w. Epub 2025 Feb 8.
2
Structure based exploration of mitochondrial alpha carbonic anhydrase inhibitors as potential leads for anti-obesity drug development.基于结构的线粒体 α 碳酸酐酶抑制剂的探索作为抗肥胖药物开发的潜在先导物。
Daru. 2024 Dec;32(2):907-924. doi: 10.1007/s40199-024-00535-w. Epub 2024 Sep 14.
3
Association between LTF/MMP20/CA6/TAS1R2 polymorphisms and susceptibility to dental caries.LTF/MMP20/CA6/TAS1R2 多态性与龋齿易感性的关系。
Clin Oral Investig. 2024 Aug 30;28(9):508. doi: 10.1007/s00784-024-05894-x.
4
Sucrose rinse modulates the salivary behavior of carbonic anhydrase VI and its buffering capacity: a longitudinal study in 4 to 6.5-year-old children.蔗糖漱口液调节碳酸酐酶 VI 的唾液行为及其缓冲能力：4 至 6.5 岁儿童的纵向研究。
PeerJ. 2024 May 30;12:e17429. doi: 10.7717/peerj.17429. eCollection 2024.
5
Identification of the Major Protein Components of Human and Cow Saliva.人和牛唾液主要蛋白质成分的鉴定
Int J Mol Sci. 2023 Nov 28;24(23):16838. doi: 10.3390/ijms242316838.
6
Mass Spectrometry-Based Proteomics for Discovering Salivary Biomarkers in Periodontitis: A Systematic Review.基于质谱的蛋白质组学在牙周炎唾液生物标志物发现中的应用：一项系统综述
Int J Mol Sci. 2023 Sep 27;24(19):14599. doi: 10.3390/ijms241914599.
7
Physical and chemical properties of saliva and its role in Early Childhood caries - A systematic review and meta-analysis.唾液的物理和化学性质及其在幼儿龋齿中的作用——一项系统综述和荟萃分析
J Oral Biol Craniofac Res. 2023 Sep-Oct;13(5):527-538. doi: 10.1016/j.jobcr.2023.05.011. Epub 2023 Jun 17.
8
Chronic exposure to multiple stressors alters the salivary proteome of piglets.慢性暴露于多种应激源会改变仔猪的唾液蛋白质组。
PLoS One. 2023 May 26;18(5):e0286455. doi: 10.1371/journal.pone.0286455. eCollection 2023.
9
Antihistamines, phenothiazine-based antipsychotics, and tricyclic antidepressants potently activate pharmacologically relevant human carbonic anhydrase isoforms II and VII.抗组胺药、吩噻嗪类抗精神病药和三环类抗抑郁药能强烈激活具有药理相关性的人碳酸酐酶同工酶 II 和 VII。
J Enzyme Inhib Med Chem. 2023 Dec;38(1):2188147. doi: 10.1080/14756366.2023.2188147.
10
The submandibular and sublingual glands maintain oral microbial homeostasis through multiple antimicrobial proteins.下颌下腺和舌下腺通过多种抗菌蛋白维持口腔微生物的稳态。
Front Cell Infect Microbiol. 2023 Jan 10;12:1057327. doi: 10.3389/fcimb.2022.1057327. eCollection 2022.
本文引用的文献
1
The biochemistry of oral calculus the presence of carbonic anhydrase in human saliva.
J Am Dent Assoc. 1946 Feb;33:191-4. doi: 10.14219/jada.archive.1946.0047.
2
Gastric carbonic anhydrase.胃碳酸酐酶
J Physiol. 1939 Nov 14;97(1):32-43. doi: 10.1113/jphysiol.1939.sp003790.
3
A demonstration of the importance of bicarbonate as a salivary buffer.
J Dent Res. 1951 Jun;30(3):403-14. doi: 10.1177/00220345510300031601.
4
The apparent first dissociation constant (pK'-1) of carbonic acid in saliva.唾液中碳酸的表观一级解离常数（pK'-1）
Arch Oral Biol. 1961 Dec;5:236-40. doi: 10.1016/0003-9969(61)90061-9.
5
An analysis of the buffer systems in saliva.
J Dent Res. 1955 Aug;34(4):516-30. doi: 10.1177/00220345550340040701.
6
Salivary carbonic anhydrase isoenzyme VI is located in the human enamel pellicle.唾液碳酸酐酶同工酶VI位于人牙釉质薄膜中。
Caries Res. 1999 May-Jun;33(3):185-90. doi: 10.1159/000016515.
7
A low concentration of carbonic anhydrase isoenzyme VI in whole saliva is associated with caries prevalence.全唾液中低浓度的碳酸酐酶同工酶VI与龋齿患病率相关。
Caries Res. 1999 May-Jun;33(3):178-84. doi: 10.1159/000016514.
8
Gustin from human parotid saliva is carbonic anhydrase VI.来自人类腮腺唾液的古斯汀是碳酸酐酶VI。
Biochem Biophys Res Commun. 1998 Sep 29;250(3):635-41. doi: 10.1006/bbrc.1998.9356.
9
Autonomic control of submandibular protein secretion in the anaesthetized calf.
Exp Physiol. 1998 Jul;83(4):545-56. doi: 10.1113/expphysiol.1998.sp004137.
10
Risks for oral health with the use of antidepressants.
Gen Hosp Psychiatry. 1998 May;20(3):150-4. doi: 10.1016/s0163-8343(98)00017-6.
Zotero 插件