Lina G, Piémont Y, Godail-Gamot F, Bes M, Peter M O, Gauduchon V, Vandenesch F, Etienne J
Centre National de Référence de Toxémies Staphylococciques, Faculté de Médecine, 69372 Lyon Cedex 08, France.
Clin Infect Dis. 1999 Nov;29(5):1128-32. doi: 10.1086/313461.
Panton-Valentine leukocidin (PVL) is a cytotoxin that causes leukocyte destruction and tissue necrosis. It is produced by fewer than 5% of Staphylococcus aureus strains. A collection of 172 S. aureus strains were screened for PVL genes by polymerase chain reaction amplification. PVL genes were detected in 93% of strains associated with furunculosis and in 85% of those associated with severe necrotic hemorrhagic pneumonia (all community-acquired). They were detected in 55% of cellulitis strains, 50% of cutaneous abscess strains, 23% of osteomyelitis strains, and 13% of finger-pulp-infection strains. PVL genes were not detected in strains responsible for other infections, such as infective endocarditis, mediastinitis, hospital-acquired pneumonia, urinary tract infection, and enterocolitis, or in those associated with toxic-shock syndrome. It thus appears that PVL is mainly associated with necrotic lesions involving the skin or mucosa.
潘顿-瓦伦丁杀白细胞素（PVL）是一种可导致白细胞破坏和组织坏死的细胞毒素。产生该毒素的金黄色葡萄球菌菌株不到5%。通过聚合酶链反应扩增对172株金黄色葡萄球菌进行了PVL基因筛查。在93%的与疖病相关的菌株以及85%的与严重坏死性出血性肺炎（均为社区获得性）相关的菌株中检测到了PVL基因。在55%的蜂窝织炎菌株、50%的皮肤脓肿菌株、23%的骨髓炎菌株和13%的指腹感染菌株中检测到了PVL基因。在导致其他感染的菌株中未检测到PVL基因，如感染性心内膜炎、纵隔炎、医院获得性肺炎、尿路感染和小肠结肠炎，或与中毒性休克综合征相关的菌株。因此，PVL似乎主要与涉及皮肤或黏膜的坏死性病变有关。
