Goldberg V M, Jinno T
Department of Orthopedics, University Hospital of Cleveland, Case Western Reserve University, OH 44106, USA.
J Long Term Eff Med Implants. 1999;9(1-2):11-21.
This study quantifies and compares bone formation on and around roughened titanium implants with roughened cobalt chromium, polished solid implants, and titanium fibermetal implants. Cylindrical rods were implanted into the medullary canal of the distal femur of rabbits. The bone-implant interface was studied 3, 6, and 12 weeks after surgery using histomorphometric methods. Roughened surface implants demonstrated significantly more bone directly apposed to the surfaces when compared to the polished or fiber/metal implants at 6 and 12 weeks after surgery. New bone formation and remodeling of bone occurred directly on roughened surfaces as late as 12 weeks after implantation, but not on the unroughened implants. These results suggest that roughening of the surfaces of both titanium and cobalt chromium implants can enhance osseointegration and may be useful clinically for the fixation of prosthetic components.
本研究对粗糙钛植入物与粗糙钴铬合金、抛光实心植入物及钛纤维金属植入物表面及其周围的骨形成进行了量化和比较。将圆柱形棒植入兔股骨远端的髓腔内。术后3周、6周和12周采用组织形态计量学方法研究骨-植入物界面。与抛光或纤维/金属植入物相比，粗糙表面植入物在术后6周和12周时，其表面直接附着的骨明显更多。新骨形成及骨重塑在植入后长达12周时直接发生于粗糙表面，但未发生于未粗糙化的植入物表面。这些结果表明，钛和钴铬合金植入物表面的粗糙化均可增强骨整合，在临床上可能有助于假体部件的固定。
