Feighan J E, Goldberg V M, Davy D, Parr J A, Stevenson S
Department of Orthopaedics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-5000, USA.
J Bone Joint Surg Am. 1995 Sep;77(9):1380-95. doi: 10.2106/00004623-199509000-00015.
The apposition of new bone to polished solid implants and to implants with surfaces that had been blasted with one of three methods of grit-blasting was studied in a rabbit intramedullary model to test the hypothesis that blasted implant surfaces support osseous integration. Intramedullary titanium-alloy (Ti-6Al-4V) plugs, press-fit into the distal aspect of the femoral canal, were implanted bilaterally in fifty-six rabbits. Four surface treatments were studied: polished (a surface roughness of 0.4 to 0.6 micrometer) and blasted with stainless-steel shot (a surface roughness of five to seven micrometers), with thirty-six-grit aluminum oxide (a surface roughness of five to seven micrometers), or with sixty-grit aluminum oxide (a surface roughness of three to five micrometers). Localized attachment of new bone to the surfaces of the blasted implants was present radiographically at twelve weeks. The total bone area was significantly affected by the level of the section (the diaphysis had a greater bone area than the proximal part of the metaphysis and the proximal part of the metaphysis had a greater bone area than the distal part of the metaphysis; p < 0.001) and the quadrant within each section (the posterior and anterior quadrants had greater bone area than the medial and lateral quadrants; p < 0.00001). The length of the bone-implant interface was significantly affected by the surface treatment (the length of the bone-implant interface for the implants that had been blasted with sixty-grit aluminum oxide was greater than the length for the polished implants; p = 0.02), the time after implantation (the interface was longer at six and twelve weeks than at three weeks; p < 0.00001), and the level of the section (the interface was longer at the diaphysis than at the proximal part of the metaphysis and longer at the proximal part of the metaphysis than at the distal part of the metaphysis; p = 0.004). Blasting of the surface of titanium-alloy implants did not have an effect on the area of bone formation around the implants, but it did significantly affect the area of bone formation on the implant and the shear strength at the bone-implant interface. The two effects were not necessarily parallel, as significantly less (p < 0.05) bone formed on implants that had been blasted with stainless-steel shot than on those blasted with aluminum grit, whereas their interface shear strengths were similar.
在兔髓内模型中，研究了新骨与经抛光的实心植入物以及表面采用三种喷砂方法之一进行喷砂处理的植入物的附着情况，以验证喷砂处理的植入物表面支持骨整合这一假设。将压配合入股骨髓腔远端的髓内钛合金（Ti-6Al-4V）栓双侧植入56只兔体内。研究了四种表面处理方式：抛光（表面粗糙度为0.4至0.6微米）以及用不锈钢丸喷砂（表面粗糙度为5至7微米）、用36目氧化铝喷砂（表面粗糙度为5至7微米）或用60目氧化铝喷砂（表面粗糙度为3至5微米）。在12周时，X线片显示新骨在喷砂处理的植入物表面有局部附着。总骨面积受截面水平（骨干的骨面积大于干骺端近端，干骺端近端的骨面积大于干骺端远端；p<0.001）以及每个截面内象限的显著影响（后象限和前象限的骨面积大于内侧象限和外侧象限；p<0.00001）。骨-植入物界面的长度受表面处理（用60目氧化铝喷砂的植入物的骨-植入物界面长度大于抛光植入物的长度；p = 0.02）、植入后时间（6周和12周时的界面比3周时更长；p<0.00001）以及截面水平的显著影响（骨干处的界面比干骺端近端更长，干骺端近端的界面比干骺端远端更长；p = 0.004）。钛合金植入物表面喷砂处理对植入物周围的骨形成面积没有影响，但对植入物上的骨形成面积以及骨-植入物界面的剪切强度有显著影响。这两种影响不一定平行，因为用不锈钢丸喷砂的植入物上形成的骨显著少于用铝砂喷砂的植入物（p<0.05），而它们的界面剪切强度相似。
