兔模型中经喷砂和双重蚀刻处理使表面粗糙化的钛植入物的骨反应。
Bone responses to titanium implants surface-roughened by sandblasted and double etched treatments in a rabbit model.
作者信息
Yang Guo-Li, He Fu-Ming, Yang Xiao-Feng, Wang Xiao-Xiang, Zhao Shi-Fang
机构信息
Department of Oral and Maxillofacial Surgery, Stomatology Hospital, School of Medical, Zhejiang University, Hangzhou, China.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Oct;106(4):516-24. doi: 10.1016/j.tripleo.2008.03.017. Epub 2008 Jul 7.
OBJECTIVE
The objective of this study was to investigate bone responses to titanium implants surface-roughened by sandblasted and double-etched treatments in a rabbit model.
STUDY DESIGN
Sixty implants of 10 mm in length (30 machined and 30 roughened) were inserted into femurs of 30 rabbits and 30 implants of 8 mm in length (15 machined and 15 roughened) were inserted into tibias of 15 rabbits. At 2, 4, and 8 weeks postimplantation, femurs and tibias were retrieved and prepared for removal torque tests (RTQ) and histomorphometric evaluation, respectively.
RESULTS
The roughened implants showed 66.21%, 89.06%, and 115.00% greater RTQ values than did the machined implants at 2, 4, and 8 weeks. Histomorphometric evaluation demonstrated the roughened implants significantly increased bone-implant contact and peri-implant bone formation during all observation periods.
CONCLUSION
These results suggest this surface-roughened approach provides the implant surface with a considerable osteoconductive potential promoting a high level of bone integration with bone.
目的
本研究的目的是在兔模型中研究经喷砂和双重蚀刻处理使表面粗糙化的钛植入物的骨反应。
研究设计
将60枚长度为10毫米的植入物（30枚机械加工的和30枚表面粗糙化的）植入30只兔子的股骨，将30枚长度为8毫米的植入物（15枚机械加工的和15枚表面粗糙化的）植入15只兔子的胫骨。在植入后2周、4周和8周，分别取出股骨和胫骨，准备进行移除扭矩测试（RTQ）和组织形态计量学评估。
结果
在2周、4周和8周时，表面粗糙化的植入物的RTQ值分别比机械加工的植入物高66.21%、89.06%和115.00%。组织形态计量学评估表明，在所有观察期内，表面粗糙化的植入物显著增加了骨-植入物接触和植入物周围的骨形成。
结论
这些结果表明，这种表面粗糙化方法为植入物表面提供了相当大的骨传导潜力，促进了与骨的高水平骨整合。
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