Wüstenberg P, Henneicke-von Zepelin H H, Köhler G, Stammwitz U
Adv Ther. 1999 Jan-Feb;16(1):51-70.
Using the example of an allopathic herbal combined preparation containing Echinacea root, wild indigo root, and white cedar leaf tips (Echinaceae radix + Baptisiae tinctoriae radix + Thujae occidentalis herba = Esberitox N), the efficacy and mode of action of a phytoimmunomodulator, or immune system enhancer, is described. Efficacy of the immunomodulator has been demonstrated in studies of acute viral respiratory tract infections and infections requiring antibiotic therapy. In a recent study compliant to GCP, the therapeutic superiority of the herbal immunomodulator over placebo was confirmed as statistically significant and clinically relevant. The present overview describes a model of the antigen-independent mode of action of phytoimmunomodulation ("immunobalancing").
以一种含有紫锥菊根、野靛蓝根和白松叶尖的对抗疗法草药复方制剂（紫锥菊根 + 北美浸液草根 + 北美香柏叶 = 埃斯贝里托克斯N）为例，阐述了植物免疫调节剂或免疫系统增强剂的功效及作用方式。免疫调节剂的功效已在急性病毒性呼吸道感染和需要抗生素治疗的感染研究中得到证实。在一项符合药品临床试验质量管理规范（GCP）的近期研究中，草药免疫调节剂相对于安慰剂的治疗优势被确认为具有统计学显著性和临床相关性。本综述描述了植物免疫调节（“免疫平衡”）的非抗原依赖性作用方式模型。
