追踪变化：抗生素与抗微生物药物耐药性的生态足迹分析。
Tracking Change: A Look at the Ecological Footprint of Antibiotics and Antimicrobial Resistance.
机构信息
Department of Civil Engineering, University of British Columbia, 2002-6250 Applied Science Lane, Vancouver, BC V6T 1Z4, Canada.
School of Population & Public Health, University of British Columbia, 2206 East Mall Vancouver, BC V6T 1Z3, Canada.
出版信息
Antibiotics (Basel). 2013 Mar 27;2(2):191-205. doi: 10.3390/antibiotics2020191.
Among the class of pollutants considered as 'emerging contaminants', antibiotic compounds including drugs used in medical therapy, biocides and disinfectants merit special consideration because their bioactivity in the environment is the result of their functional design. Antibiotics can alter the structure and function of microbial communities in the receiving environment and facilitate the development and spread of resistance in critical species of bacteria including pathogens. Methanogenesis, nitrogen transformation and sulphate reduction are among the key ecosystem processes performed by bacteria in nature that can also be affected by the impacts of environmental contamination by antibiotics. Together, the effects of the development of resistance in bacteria involved in maintaining overall ecosystem health and the development of resistance in human, animal and fish pathogens, make serious contributions to the risks associated with environmental pollution by antibiotics. In this brief review, we discuss the multiple impacts on human and ecosystem health of environmental contamination by antibiotic compounds.
在被认为是“新兴污染物”的一类污染物中，包括用于医疗治疗的药物、杀生剂和消毒剂在内的抗生素化合物值得特别关注，因为它们在环境中的生物活性是其功能设计的结果。抗生素可以改变接受环境中微生物群落的结构和功能，并促进包括病原体在内的关键细菌物种的耐药性的发展和传播。产甲烷作用、氮转化和硫酸盐还原是细菌在自然界中进行的关键生态系统过程，抗生素对其的环境污染也会对这些过程产生影响。细菌耐药性的发展对维持整个生态系统健康的细菌以及人类、动物和鱼类病原体的耐药性的发展的影响，使得抗生素对环境污染相关风险的贡献严重。在这篇简要的综述中，我们讨论了抗生素化合物对人类和生态系统健康的多种影响。
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