Sävendahl L, Underwood L E
Department of Pediatrics, Division of Endocrinology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7220, USA.
J Nutr. 1999 Nov;129(11):2005-8. doi: 10.1093/jn/129.11.2005.
Voluntary fasting is practiced by many humans in an attempt to lose body weight. Conflicting results have been published on the effects of food deprivation on serum lipids. To study the effect of acute starvation on serum lipids, 10 nonobese (93-124% of ideal body weight), healthy adults (6 men, 4 women, 21-38 y old) fasted (no energy) for 7 d. Fasting increased total serum cholesterol from 4.90 +/- 0.23 to 6.73 +/- 0.41 mmol/L (37.3 +/- 5.0%; P < 0.0001) and LDL cholesterol from 2.95 +/- 0.21 to 4.90 +/- 0.36 mmol/L (66.1 +/- 6. 6%; P < 0.0001). Serum apolipoprotein B (apo B) increased from 0.84 +/- 0.06 to 1.37 +/- 0.11 g/L (65.0 +/- 9.2%; P < 0.0001). The increases in serum cholesterol, LDL and apo B were associated with weight loss. Fasting did not affect serum concentrations of triacylglycerol and HDL cholesterol. Serum concentrations of insulin-like growth factor-I (IGF-I) decreased from 246 +/- 29 (prefast) to 87 +/- 10 microg/L after 1 wk of fasting (P < 0.0001). We conclude that, in nonobese subjects, fasting is accompanied by increases in serum cholesterol, LDL and apo B concentrations, whereas IGF-I levels are decreased.
许多人为了减肥而进行自愿禁食。关于食物剥夺对血脂的影响，已发表了相互矛盾的结果。为了研究急性饥饿对血脂的影响，10名非肥胖（理想体重的93 - 124%）、健康的成年人（6名男性，4名女性，21 - 38岁）禁食（无能量摄入）7天。禁食使血清总胆固醇从4.90±0.23 mmol/L升至6.73±0.41 mmol/L（升高37.3±5.0%；P<0.0001），低密度脂蛋白胆固醇从2.95±0.21 mmol/L升至4.90±0.36 mmol/L（升高66.1±6.6%；P<0.0001）。血清载脂蛋白B（apo B）从0.84±0.06 g/L升至1.37±0.11 g/L（升高65.0±9.2%；P<0.0001）。血清胆固醇、低密度脂蛋白和apo B的升高与体重减轻有关。禁食不影响血清三酰甘油和高密度脂蛋白胆固醇的浓度。禁食1周后，胰岛素样生长因子-I（IGF-I）的血清浓度从246±29（禁食前）降至87±10 μg/L（P<0.0001）。我们得出结论，在非肥胖受试者中，禁食伴随着血清胆固醇、低密度脂蛋白和apo B浓度的升高，而IGF-I水平降低。
