John W Garry, Noonan Kate, Mannan Nasima, Boucher Barbara J
Centre for Diabetes and Metabolic Medicine, Queen Mary School of Medicine and Dentistry, University of London, London, United Kingdom.
Am J Clin Nutr. 2005 Sep;82(3):517-22. doi: 10.1093/ajcn.82.3.517.
Although hypovitaminosis D has been suggested to increase the risk of heart disease, its relation to components of the fasting lipid profile has not been clarified for specific ethnic groups.
The objective was to determine the relation of circulating 25-hydroxyvitamin D [25(OH)D] concentrations to fasting lipid concentrations in South Asian subjects at risk of hypovitaminosis D.
The present study was conducted in 170 British Bangladeshi adults, 69 men and 101 women, from east London who were free of known diabetes or chronic disorders. Vitamin D repletion was assessed by measuring fasting serum 25(OH)D concentrations. Fasting lipid profiles were measured as part of a study of the risk factors for type 2 diabetes and ischemic heart disease, which included hypovitaminosis D.
A univariate analysis showed that total cholesterol, LDL cholesterol, and both apolipoprotein (apo) A-I and apo B concentrations correlated directly with serum 25(OH)D concentrations. However, a multiple regression analysis, which included all the documented risk factors for diabetes and ischemic heart disease, showed that the 25(OH)D concentration (vitamin D status) was an independent predictor of increasing apo A-I concentrations (standardized coefficient beta = 0.3; P < 0.001) but not of fasting lipid concentrations.
In this study of British South Asians, the data showed a positive relation of fasting apo A-I concentrations to serum 25(OH)D concentrations, independent of glycemia and other dietary, anthropometric, and lifestyle risk factors for type 2 diabetes and ischemic heart disease after multiple regression analyses. Subjects with hypovitaminosis D are likely to have an increased risk of ischemic heart disease independent of their increased risk of type 2 diabetes.
尽管维生素D缺乏症被认为会增加患心脏病的风险，但对于特定种族群体，其与空腹血脂谱各成分之间的关系尚未明确。
确定维生素D缺乏风险较高的南亚受试者中循环25-羟维生素D[25(OH)D]浓度与空腹血脂浓度之间的关系。
本研究对170名来自伦敦东部的英国孟加拉裔成年人进行，其中男性69名，女性101名，这些人无已知糖尿病或慢性疾病。通过测量空腹血清25(OH)D浓度评估维生素D补充情况。作为2型糖尿病和缺血性心脏病危险因素研究的一部分，测量空腹血脂谱，该研究包括维生素D缺乏症。
单因素分析显示，总胆固醇、低密度脂蛋白胆固醇以及载脂蛋白（apo）A-I和apo B浓度均与血清25(OH)D浓度直接相关。然而，多因素回归分析纳入了所有记录在案的糖尿病和缺血性心脏病危险因素，结果显示25(OH)D浓度（维生素D状态）是apo A-I浓度升高的独立预测因素（标准化系数β=0.3；P<0.001），但不是空腹血脂浓度的独立预测因素。
在这项针对英国南亚人的研究中，数据显示空腹apo A-I浓度与血清25(OH)D浓度呈正相关，在多因素回归分析后，独立于血糖以及2型糖尿病和缺血性心脏病的其他饮食、人体测量和生活方式危险因素。维生素D缺乏的受试者患缺血性心脏病的风险可能增加，这独立于他们患2型糖尿病风险的增加。
