临床重要葡萄球菌中插入序列样元件IS1272的分布及其与耐甲氧西林基因的相对位置
Distribution of insertion sequence-like element IS1272 and its position relative to methicillin resistance genes in clinically important Staphylococci.
作者信息
Kobayashi N, Urasawa S, Uehara N, Watanabe N
机构信息
Department of Hygiene, Sapporo Medical University School of Medicine, Chuo-ku, Sapporo 060-8556, Japan.
出版信息
Antimicrob Agents Chemother. 1999 Nov;43(11):2780-2. doi: 10.1128/AAC.43.11.2780.
Abstract
The distribution of insertion sequence-like element IS1272 was analyzed for clinical isolates of Staphylococcus aureus, Staphylococcus epidermidis, and Staphylococcus haemolyticus. In each of the staphylococcal species, IS1272 was detected in both methicillin-resistant (MR) and methicillin-susceptible strains of different genetic types. In MR isolates, IS1272 was generally located downstream of the truncated mecR1 gene (DeltamecR1), with an identical junction sequence occurring between DeltamecR1 and IS1272, although insertion of an additional gene sequence in the junction sequence was detected in one S. epidermidis isolate. These findings suggest that the mec element with the rearranged form of mecR1 (DeltamecR1-IS1272) has been transmitted to multiple clones of staphylococci.
摘要
对金黄色葡萄球菌、表皮葡萄球菌和溶血葡萄球菌的临床分离株进行了类插入序列元件IS1272的分布分析。在每种葡萄球菌中，不同基因类型的耐甲氧西林（MR）菌株和甲氧西林敏感菌株中均检测到IS1272。在MR分离株中，IS1272通常位于截短的mecR1基因（DeltamecR1）下游，DeltamecR1和IS1272之间存在相同的连接序列，不过在一株表皮葡萄球菌分离株中检测到连接序列中有一个额外基因序列插入。这些发现表明，具有重排形式mecR1（DeltamecR1-IS1272）的mec元件已传播至葡萄球菌的多个克隆。
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