酮内酯类药物HMR 3647、大环内酯类药物及克林霉素对棒状杆菌的体外活性
In vitro activities of ketolide HMR 3647, macrolides, and clindamycin against Coryneform bacteria.
作者信息
Martínez-Martínez L, Pascual A, Suárez A I, Perea E J
机构信息
Department of Microbiology, Hospital Universitario Virgen Macarena, Seville, Spain.
出版信息
Antimicrob Agents Chemother. 1998 Dec;42(12):3290-2. doi: 10.1128/AAC.42.12.3290.
Abstract
The in vitro activity of ketolide HMR 3647 against coryneform bacteria isolated from clinical samples was evaluated. Except against Corynebacterium jeikeium and C. urealyticum, HMR 3647 showed high activity against Corynebacterium spp., being more active than 14- and 16-membered macrolides, azithromycin, or clindamycin. HMR 3647 also had high in vitro activity against Brevibacterium spp. and Listeria monocytogenes.
摘要
对酮内酯类药物HMR 3647针对从临床样本中分离出的棒状杆菌的体外活性进行了评估。除了对杰氏棒状杆菌和解脲棒状杆菌外，HMR 3647对棒状杆菌属显示出高活性，比14元和16元大环内酯类、阿奇霉素或克林霉素更具活性。HMR 3647对短杆菌属和单核细胞增生李斯特菌也具有高体外活性。
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