6'-N-乙酰基转移酶Ib型【AAC(6')-Ib】中F171突变对氨基糖苷类药物敏感性的影响。
Effects of F171 mutations in the 6'-N-acetyltransferase type Ib [AAC(6')-Ib] enzyme on susceptibility to aminoglycosides.
作者信息
Chavideh R, Sholly S, Panaite D, Tolmasky M E
机构信息
Institute of Molecular Biology, Department of Biological Science, School of Natural Sciences and Mathematics, California State University Fullerton, Fullerton, California 92834-6850, USA.
出版信息
Antimicrob Agents Chemother. 1999 Nov;43(11):2811-2. doi: 10.1128/AAC.43.11.2811.
Abstract
Substitutions at position F171 of 6'-N-acetyltransferase type Ib cause variable loss of aminoglycoside resistance, indicating that this residue plays an important role in the structure and/or function of the enzyme.
摘要
6'-N-乙酰基转移酶Ib型F171位的替换导致氨基糖苷类耐药性的可变丧失，表明该残基在酶的结构和/或功能中起重要作用。
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