着色性干皮病细胞中光复活酶水平较低。
Xeroderma pigmentosum cells contain low levels of photoreactivating enzyme.
作者信息
Sutherland B M, Rice M, Wagner E K
出版信息
Proc Natl Acad Sci U S A. 1975 Jan;72(1):103-7. doi: 10.1073/pnas.72.1.103.
Abstract
Fibroblasts from patients with xeroderma pigmentosum contain low levels of photoreactivating enzyme in comparison to normal cells. Levels vary from 0 (line 1199) to 50 (line 1259) percent of normal. The depressed enzyme levels are not an artifact of low growth rate, age of cell donor, cell culture conditions, assay conditions, the presence of inhibitors, or mycoplasma contamination. We show that human fibroblasts can monomerize pyrimidine dimers in vivo.
摘要
与正常细胞相比，着色性干皮病患者的成纤维细胞中光复活酶水平较低。其水平在正常水平的0%（1199系）至50%（1259系）之间变化。酶水平降低并非低生长速率、细胞供体年龄、细胞培养条件、检测条件、抑制剂存在或支原体污染造成的假象。我们表明，人类成纤维细胞在体内可使嘧啶二聚体单体化。
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Proc Natl Acad Sci U S A. 1975 Jan;72(1):103-7. doi: 10.1073/pnas.72.1.103.
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