Pfeifer U, Aterman K
Virchows Arch B Cell Pathol. 1979 Feb 6;29(4):229-43. doi: 10.1007/BF02899356.
A liver biopsy specimen from a case of primary amyloidosis was investigated by electron microscopy. The cytoplasmic periphery of the hepatocytes showed degenerativechanges which are interpreted as indicating shedding of peripheral parts of the cytoplasm. Two main variants of this process could be discerned: 1) Protrusion and sequestration of hernia-like blebs of cytoplasm, and 2) shedding of vesicles derived from degenerated endoplasmic reticulum. In the latter case transient defects of the plasma membrane seem to be relevance. Endoplasmic reticulum and cytoplasmic ground substance appeared to be shed preferentially, whereas mitochondria are retained within the cell. As a consequence the fractional volume of the mitochondria in the cytoplasm of atrophic cells is markedly increased. Shedding of peripheral cytoplasm, therefore, seems to be an effective mechanism enabeling the cell to adapt the mass and the composition of its cytoplasm to an unfavourable environment.
对一例原发性淀粉样变性患者的肝活检标本进行了电子显微镜检查。肝细胞的细胞质周边显示出退行性变化，这被解释为表明细胞质周边部分的脱落。可以识别出这个过程的两种主要变体：1）细胞质的疝样小泡的突出和隔离，以及2）源自退化内质网的小泡的脱落。在后一种情况下，质膜的短暂缺陷似乎是相关的。内质网和细胞质基质似乎优先脱落，而线粒体则保留在细胞内。因此，萎缩细胞细胞质中线粒体的分数体积显著增加。因此，周边细胞质的脱落似乎是一种有效的机制，使细胞能够使其细胞质的质量和组成适应不利的环境。
