Behravesh E, Yasko A W, Engel P S, Mikos A G
Department of Bioengineering, Rice University, Houston, Texas 77005-1892, USA.
Clin Orthop Relat Res. 1999 Oct(367 Suppl):S118-29. doi: 10.1097/00003086-199910001-00012.
Synthetic biodegradable polymers offer an alternative to the use of autografts, allografts, and nondegradable materials for bone replacement. They can be synthesized with tailored mechanical and degradative properties. They also can be processed to porous scaffolds with desired pore morphologic features conducive to tissue ingrowth. Moreover, functionalized polymers can modulate cellular function and induce tissue ingrowth. This review focuses on four classes of polymers that hold promise for orthopaedic applications: poly alpha-hydroxy esters, polyphosphazenes, polyanhydrides, and polypropylene fumarate crosslinked networks.
合成可生物降解聚合物为使用自体移植物、同种异体移植物和不可降解材料进行骨替代提供了一种替代方案。它们可以被合成出具有定制的机械性能和降解性能。它们还可以被加工成具有有利于组织向内生长的所需孔隙形态特征的多孔支架。此外，功能化聚合物可以调节细胞功能并诱导组织向内生长。本综述重点关注在骨科应用中有前景的四类聚合物：聚α-羟基酯、聚磷腈、聚酸酐和富马酸聚丙烯交联网络。
