Walton S F, Choy J L, Bonson A, Valle A, McBroom J, Taplin D, Arlian L, Mathews J D, Currie B, Kemp D J
Menzies School of Health Research, Darwin, Northern Territory, Australia.
Am J Trop Med Hyg. 1999 Oct;61(4):542-7. doi: 10.4269/ajtmh.1999.61.542.
Overcrowding is a significant factor contributing to endemic infection with Sarcoptes scabiei in human and animal populations. However, since scabies mites from different host species are indistinguishable morphologically, it is unclear whether people can be infected from scabies-infested animals. Molecular fingerprinting was done using three S. scabiei-specific single locus hypervariable microsatellite markers, with a combined total of 70 known alleles. Multilocus analysis of 712 scabies mites from human and dog hosts in Ohio, Panama and Aboriginal communities in northern Australia now shows that genotypes of dog-derived and human-derived scabies cluster by host species rather than by geographic location. Because of the apparent genetic separation between human scabies and dog scabies, control programs for human scabies in endemic areas do not require resources directed against zoonotic infection from dogs.
过度拥挤是导致人类和动物群体感染疥螨的一个重要因素。然而，由于来自不同宿主物种的疥螨在形态上无法区分，因此尚不清楚人类是否会被感染疥螨的动物传染。使用三个疥螨特异性单基因座高变微卫星标记进行分子指纹分析，共有70个已知等位基因。对来自俄亥俄州、巴拿马和澳大利亚北部原住民社区的人类和犬类宿主的712只疥螨进行多位点分析，结果表明，来自犬类和人类的疥螨基因型按宿主物种聚类，而非地理位置。由于人类疥螨和犬类疥螨之间存在明显的遗传分离，因此流行地区的人类疥疮控制项目无需投入资源预防来自犬类的人畜共患感染。
