Chen T S, Chang F Y, Lee S D
Department of Medicine, Veterans General Hospital-Taipei, Taiwan.
Dig Dis Sci. 1999 Oct;44(10):2076-80. doi: 10.1023/a:1026634721351.
The aim of this study was to examine the seroprevalence of antibody to CagA antigen, as well as other major H. pylori antigens by Western blot in H. pylori-infected subjects with endoscopically normal mucosa (N = 54) and duodenal ulcer (N = 51). The role of the host and environmental factors was also evaluated. There was no significant difference in the prevalence of antibodies against the major H. pylori antigens between the two groups. A high prevalence of antibody to CagA was detected in patients with normal mucosa (93%) and duodenal ulcer (86%). Multivariate analysis shows that male gender (odds ratio = 4.94, 95% CI = 1.39-17.77, P = 0.014) and smoking (odds ratio = 8.89, 95% CI = 2.17-36.48, P = 0.002) were associated with duodenal ulcer disease. This study suggests that smoking and male gender rather than CagA protein are associated with increased risk for duodenal ulcer in H. pylori-infected patients in Taiwan.
本研究旨在通过蛋白质印迹法检测幽门螺杆菌（H. pylori）感染且内镜检查黏膜正常的受试者（N = 54）和十二指肠溃疡患者（N = 51）中抗CagA抗原抗体以及其他主要幽门螺杆菌抗原的血清阳性率。同时还评估了宿主和环境因素的作用。两组之间针对主要幽门螺杆菌抗原的抗体阳性率无显著差异。在黏膜正常的患者（93%）和十二指肠溃疡患者（86%）中均检测到高比例的抗CagA抗体。多因素分析显示，男性（比值比 = 4.94，95%置信区间 = 1.39 - 17.77，P = 0.014）和吸烟（比值比 = 8.89，95%置信区间 = 2.17 - 36.48，P = 0.002）与十二指肠溃疡疾病相关。本研究表明，在台湾幽门螺杆菌感染患者中，吸烟和男性性别而非CagA蛋白与十二指肠溃疡风险增加相关。
