Wu Hui-Chao, Tuo Bi-Guang, Wu Wei-Min, Gao Yuan, Xu Qing-Qing, Zhao Kui
Department of Gastroenterology, Affiliated Hospital, Zunyi Medical College, Zunyi, 563003, China.
Dig Dis Sci. 2008 Oct;53(10):2650-6. doi: 10.1007/s10620-007-0177-7. Epub 2008 Feb 13.
We investigated the prevalence of peptic ulcer in dyspeptic patients in China to analyze the influence of age, sex, and Helicobacter pylori (H. pylori) infection. The results showed that the prevalence of gastric and duodenal ulcer increased with age. In patients under 60 years old, the prevalence of duodenal and gastric ulcers in females was markedly lower than that in males, especially the prevalence of duodenal ulcer. The prevalence of duodenal ulcer and gastric ulcer in H. pylori-infected patients was markedly higher than in patients without H. pylori infection. In the patients under 60 years old, sex differences were still seen in both H. pylori-positive and H. pylori-negative patients. The prevalence of gastric and duodenal ulcers was markedly increased with age in both H. pylori-positive and H. pylori-negative patients. Multivariate logistic regression analysis showed that age, male sex, and H. pylori infection were three independent risk factors for gastric and duodenal ulcers.
我们调查了中国消化不良患者消化性溃疡的患病率，以分析年龄、性别和幽门螺杆菌（H. pylori）感染的影响。结果显示，胃溃疡和十二指肠溃疡的患病率随年龄增长而增加。在60岁以下的患者中，女性十二指肠溃疡和胃溃疡的患病率明显低于男性，尤其是十二指肠溃疡的患病率。幽门螺杆菌感染患者的十二指肠溃疡和胃溃疡患病率明显高于未感染幽门螺杆菌的患者。在60岁以下的患者中，幽门螺杆菌阳性和阴性患者均存在性别差异。幽门螺杆菌阳性和阴性患者的胃溃疡和十二指肠溃疡患病率均随年龄显著增加。多因素logistic回归分析表明，年龄、男性性别和幽门螺杆菌感染是胃溃疡和十二指肠溃疡的三个独立危险因素。
