药物与核酸插入结合的X射线晶体学可视化：溴化乙锭-二核苷单磷酸晶体复合物的结构，溴化乙锭：5-碘尿苷酰基（3'-5'）腺苷。
X-ray crystallographic visualization of drug-nucleic acid intercalative binding: structure of an ethidium-dinucleoside monophosphate crystalline complex, Ethidium: 5-iodouridylyl (3'-5') adenosine.
作者信息
Tsai C C, Jain S C, Sobell H M
出版信息
Proc Natl Acad Sci U S A. 1975 Feb;72(2):628-32. doi: 10.1073/pnas.72.2.628.
Abstract
We have cocrystallized the drug ethidium bromide with the dinucleoside monophosphate 5-iodouridylyl(3'-5')adenosine and have solved the three-dimensional structure to atomic resolution by x-ray crystallography. This has allowed the direct visualization of intercalative binding by this drug to a fragment of a nucleic acid double helix.
摘要
我们已将药物溴化乙锭与二核苷单磷酸5-碘尿苷酰（3'-5'）腺苷共结晶，并通过X射线晶体学解析出了原子分辨率的三维结构。这使得能够直接观察到该药物与核酸双螺旋片段的嵌入结合。
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X-ray crystallographic visualization of drug-nucleic acid intercalative binding: structure of an ethidium-dinucleoside monophosphate crystalline complex, Ethidium: 5-iodouridylyl (3'-5') adenosine.药物与核酸插入结合的X射线晶体学可视化：溴化乙锭-二核苷单磷酸晶体复合物的结构，溴化乙锭：5-碘尿苷酰基（3'-5'）腺苷。
Proc Natl Acad Sci U S A. 1975 Feb;72(2):628-32. doi: 10.1073/pnas.72.2.628.
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