溴化乙锭与核酸的非嵌入结合：溴化乙锭-tRNA分子复合物的晶体结构
Nonintercalative binding of ethidium bromide to nucleic acids: crystal structure of an ethidium--tRNA molecular complex.
作者信息
Liebman M, Rubin J, Sundaralingam M
出版信息
Proc Natl Acad Sci U S A. 1977 Nov;74(11):4821-5. doi: 10.1073/pnas.74.11.4821.
Abstract
X-ray diffraction studies at 4.5-A resolution on crystals of a complex of ethidium bromide and yeast phenylalanine tRNA reveal a nonintercalative model of binding of the ethidium within the tertiary structure. This is contrary to the expected interacalative binding to the double-helical regions.
摘要
对溴化乙锭与酵母苯丙氨酸tRNA复合物晶体进行的4.5埃分辨率的X射线衍射研究揭示了溴化乙锭在三级结构内的一种非嵌入结合模式。这与预期的与双螺旋区域的嵌入结合相反。
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