Jauniaux E, Watson A, Ozturk O, Quick D, Burton G
Academic Departments of Obstetrics and Gynaecology, and Anaesthetics, University College London (UCL), London and Department of Anatomy, University of Cambridge, Cambridge, UK.
Hum Reprod. 1999 Nov;14(11):2901-4. doi: 10.1093/humrep/14.11.2901.
A new multiparameter sensor that combines electrochemical and fibre-optic technology was used for continuous in-vivo investigation of pH, carbon dioxide partial pressure (PCO(2)), oxygen partial pressure (PO(2)), bicarbonate concentration (HCO(3)(-)), base excess, and oxygen saturation (O(2)Sat) early in human pregnancy. The sensor was inserted into the amniotic cavity and the placental bed of 16 pregnancies at 10-15 weeks gestation, before termination under general anaesthesia. Amniotic fluid and retroplacental blood from the same site were also aspirated and analysed by means of cartridges and a portable blood gas analyser. Eleven series of measurements were obtained. The variation in measurements over the 5 min of monitoring was </=10% for all parameters. The sensor was damaged during insertion into the amniotic cavity in one case and in the placental bed in four cases. Measurements of PO(2) in both the amniotic cavity and the placental bed and of pH in the placental bed were higher using the cartridges than in vivo. The results indicated that in-vivo monitoring of fetoplacental gas and acid-base with a sensor is stable and accurate. Such technology will be helpful in improving our understanding of the fetoplacental metabolism in normal and complicated pregnancies.
一种结合了电化学和光纤技术的新型多参数传感器被用于在人类妊娠早期对pH值、二氧化碳分压（PCO₂）、氧分压（PO₂）、碳酸氢盐浓度（HCO₃⁻）、碱剩余和氧饱和度（O₂Sat）进行连续的体内研究。在全身麻醉下终止妊娠前，将该传感器插入16例妊娠10至15周的羊膜腔和胎盘床。同时从同一部位抽取羊水和胎盘后血液，并用试剂盒和便携式血气分析仪进行分析。共获得了11组测量数据。在5分钟的监测过程中，所有参数的测量值变化均≤10%。有1例在将传感器插入羊膜腔时受损，4例在插入胎盘床时受损。使用试剂盒测得的羊膜腔和胎盘床的PO₂以及胎盘床的pH值均高于体内测量值。结果表明，使用传感器对胎儿-胎盘气体和酸碱进行体内监测是稳定且准确的。此类技术将有助于增进我们对正常和复杂妊娠中胎儿-胎盘代谢的理解。
