Schwartz A L
University of Washington, School of Nursing, Seattle 98195-7266, USA.
Qual Life Res. 1999 Sep;8(6):529-38. doi: 10.1023/a:1008978611274.
Fatigue is a common side effect of cancer treatment that impacts quality of life. Exercise is one approach suggested to improve fatigue. The purpose of this study was to explore the relationship of exercise to fatigue and quality of life.
Thirty-one subjects with breast cancer were enrolled prior to beginning chemotherapy and 27 completed the study. All baseline measures were obtained before the first chemotherapy treatment. Subjects were instructed on a home-based, 8-week exercise program.
Women who adopted the exercise program (60%) showed significant increases in functional ability and less weight gain. Exploratory, stepwise multiple regression analyses suggested that the maximum effect of exercise on quality of life outcomes may be mediated by fatigue.
The low-to-moderate intensity, home-based exercise program was feasible for some women with breast cancer receiving chemotherapy. The results suggest that exercise may affect quality of life and that this effect may be mediated by the effects of exercise on fatigue. Better retention of functional ability and better weight control are additional possible benefits of exposing breast cancer patients to increased exercise. A randomized, controlled clinical trial is needed to establish confidence in these observed relationships.
疲劳是癌症治疗常见的副作用，会影响生活质量。运动是被建议用来改善疲劳的一种方法。本研究的目的是探讨运动与疲劳及生活质量之间的关系。
31名乳腺癌患者在开始化疗前入组，27名完成了研究。所有基线测量均在首次化疗前进行。受试者接受了一项为期8周的家庭运动计划指导。
采用运动计划的女性（60%）功能能力显著提高，体重增加较少。探索性逐步多元回归分析表明，运动对生活质量结果的最大影响可能由疲劳介导。
低至中等强度的家庭运动计划对一些接受化疗的乳腺癌女性可行。结果表明运动可能影响生活质量，且这种影响可能由运动对疲劳的作用介导。让乳腺癌患者增加运动量的其他可能益处是更好地保持功能能力和更好地控制体重。需要进行一项随机对照临床试验来确定对这些观察到的关系的信心。
