Bauer A, Greif C, Gebhardt M, Elsner P
Klinik für Hautkrankheiten, Friedrich-Schiller-Universität, Jena.
Dtsch Med Wochenschr. 1999 Oct 8;124(40):1168-70. doi: 10.1055/s-2007-1024509.
A 49-year-old woman presented with acute perianal vesicular/bullous contact dermatitis. Other areas were over the trunk, face, neck and wrists. She reported occasional application of an ointment (Mastu S) to treat her hemorrhoids.
Patch tests (basic series, anal block, own ointment, local anesthetic, cosmetics) provoked strong vesicular and bullous reactions of persisting crescendo type, spreading far beyond the site of application, to Bufexamac, to a derivative of hydroxxamine acid, and to local applied ointment with mild or moderate antiinflammatory action.
A week after the patch tests there was a flare-up of the previous foci of dermatitis. These reactions subsided two days later after intravenous injection of prednisolone. The skin lesions healed after rapid reduction of the systemic treatment and local application of corticosteroids, bathing with tanning substances and basic preparations.
While Bufexamac is not absorbed when applied rectally, perianal contamination may not be avoidable on intra-anal application and can produce sensitization.
一名49岁女性出现急性肛周水疱/大疱性接触性皮炎。其他受累部位包括躯干、面部、颈部和手腕。她报告偶尔使用一种药膏（马苏S）治疗痔疮。
斑贴试验（基础系列、肛门阻滞、自用软膏、局部麻醉剂、化妆品）对丁苯羟酸、羟肟酸衍生物以及局部应用的具有轻度或中度抗炎作用的软膏引发了持续增强型的强烈水疱和大疱反应，反应范围远远超出涂抹部位。
斑贴试验一周后，先前的皮炎病灶出现 flare-up。静脉注射泼尼松龙两天后这些反应消退。在全身治疗迅速减量并局部应用皮质类固醇、用鞣剂和基础制剂沐浴后，皮肤病变愈合。
虽然丁苯羟酸经直肠给药时不被吸收，但肛门内应用时肛周污染可能无法避免，并且会产生致敏作用。
