Preis S, Steinmetz H, Knorr U, Jäncke L
Department of Pediatrics, Heinrich-Heine-University Düsseldorf, Moorenstr. 5, D-40225, Düsseldorf, Germany.
Brain Res Cogn Brain Res. 2000 Sep;10(1-2):37-44. doi: 10.1016/s0926-6410(00)00020-3.
Using high-resolution in-vivo magnetic resonance morphometry of the midsagittal area of the corpus callosum (CC) and four callosal subareas in 21 children with developmental language disorder (DLD) of the phonologic-syntactic type we found no significant anatomical differences in comparison to an age- and gender-matched normal control group. There was also no significant between-group difference when the approximately 7% smaller forebrain volume among children with DLD was accounted for by relating CC measures to forebrain volume. Only a tendency towards a larger anterior and middle CC in relation to forebrain volume was found in DLD children. In our DLD children we found the same relationship between CC midsagittal size and forebrain volume as recently reported for normal adults, namely, that the CC area increases to the two-third power of forebrain volume.
我们对21名患有音韵-句法类型发育性语言障碍（DLD）的儿童的胼胝体（CC）矢状面中部区域和四个胼胝体亚区域进行了高分辨率活体磁共振形态测量，结果发现，与年龄和性别匹配的正常对照组相比，并无显著的解剖学差异。当通过将CC测量值与前脑体积相关联来解释DLD儿童中约小7%的前脑体积时，组间也没有显著差异。在DLD儿童中，仅发现相对于前脑体积而言，CC前部和中部有增大的趋势。在我们的DLD儿童中，我们发现CC矢状面大小与前脑体积之间的关系与最近报道的正常成年人相同，即CC面积随前脑体积的三分之二次幂增加。
