0.5%噻吗洛尔与0.5%噻吗洛尔长效制剂治疗剥脱性青光眼和原发性开角型青光眼的24小时眼压控制比较

Comparison of 24 hour control with Timoptic 0.5% and Timoptic-XE 0.5% in exfoliation and primary open-angle glaucoma.

作者信息

Konstas A G, Mantziris D A, Maltezos A, Cate E A, Stewart W C

机构信息

University Department of Ophthalmology, AHEPA Hospital, Thessaloniki, Greece.

出版信息

Acta Ophthalmol Scand. 1999 Oct;77(5):541-3. doi: 10.1034/j.1600-0420.1999.770511.x.

DOI:10.1034/j.1600-0420.1999.770511.x

PMID:10551296

Abstract

PURPOSE

To compare the 24 hour intraocular pressure (IOP) curve in exfoliation glaucoma (EXG) and primary open-angle glaucoma (POAG) patients treated first with timolol solution 0.5% (TS) twice daily and then with timolol maleate gel forming solution 0.5% (TXE) once daily.

METHODS

We prospectively investigated age-matched, newly diagnosed EXG (n = 25) and POAG (n = 25) patients who were admitted as in-patients for 24 hour phasing first with TS and then TXE.

RESULTS

Generally TS and TXE controlled both POAG and EXG patients in a similar fashion. However, a trend to lower pressures was observed in both EXG and POAG patients with TS therapy. At two time points (10:00 and 22:00) in POAG patients, TS (18.4 +/- 3.7 and 17.2 +/- 3.1 mm Hg, respectively) provided lower intraocular pressures than TXE (19.8 +/- 3.5 and 18.9 +/- 3.8 mm Hg, respectively) (p < 0.05).

CONCLUSION

Both TS twice daily and TXE once daily control POAG and EXG generally to a similar extent.

摘要

目的

比较剥脱性青光眼（EXG）和原发性开角型青光眼（POAG）患者的24小时眼压曲线。这些患者首先每日两次使用0.5%噻吗洛尔溶液（TS）治疗，然后每日一次使用0.5%噻吗洛尔马来酸盐凝胶形成溶液（TXE）治疗。

方法

我们前瞻性地研究了年龄匹配、新诊断的EXG（n = 25）和POAG（n = 25）患者，这些患者作为住院患者入院，首先用TS进行24小时分期，然后用TXE。

结果

一般来说，TS和TXE以相似的方式控制POAG和EXG患者。然而，在接受TS治疗的EXG和POAG患者中均观察到眼压有降低的趋势。在POAG患者的两个时间点（10:00和22:00），TS（分别为18.4 +/- 3.7和17.2 +/- 3.1 mmHg）提供的眼压低于TXE（分别为19.8 +/- 3.5和18.9 +/- 3.8 mmHg）（p < 0.05）。