Fukuchi Takeo, Ueda Jun, Yaoeda Kiyoshi, Suda Kieko, Seki Masaaki, Abe Haruki
Division of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.
Jpn J Ophthalmol. 2006 Sep-Oct;50(5):455-459. doi: 10.1007/s10384-006-0346-9.
To verify that postoperative management affects the outcome of mitomycin C (MMC) trabeculectomy and suture lysis.
A total of 108 eyes in 108 Japanese patients were treated with MMC trabeculectomy. They were divided into two groups based on when the operation was performed: group A, 57 eyes in 1998, and group B, 51 eyes in 2001. The results, including postoperative intraocular pressure (IOP), complications, and postoperative management, were compared between groups. In addition, they were evaluated by a Kaplan-Meier life-table analysis.
Postoperative IOP was lower and the probability of success by life-table analysis was higher in group B than in group A. Postoperative management, including laser suture lysis and subconjunctival injection of 5-fluorouracil, was started significantly earlier in group B than in group A patients. Although more postoperative complications occurred in group B, none were severe and all were adequately managed.
Starting postoperative management earlier, particularly laser suture lysis, may be necessary to achieve lower and longer IOP control in MMC trabeculectomy.
验证术后管理对丝裂霉素C（MMC）小梁切除术及缝线溶解结果的影响。
108例日本患者的108只眼接受了MMC小梁切除术。根据手术时间将其分为两组：A组，1998年的57只眼；B组，2001年的51只眼。比较两组的结果，包括术后眼压（IOP）、并发症及术后管理情况。此外，采用Kaplan-Meier生存表分析对其进行评估。
B组术后眼压较低，生存表分析显示成功概率高于A组。B组患者开始包括激光缝线溶解及结膜下注射5-氟尿嘧啶在内的术后管理明显早于A组患者。虽然B组术后并发症更多，但均不严重且均得到妥善处理。
在MMC小梁切除术中，更早开始术后管理，尤其是激光缝线溶解，可能是实现更低且更持久眼压控制所必需的。
