Singelyn F J, Seguy S, Gouverneur J M
Department of Anesthesiology, Université Catholique de Louvain School of Medicine, St Luc Hospital, Brussels, Belgium.
Anesth Analg. 1999 Nov;89(5):1216-20.
In this prospective, randomized, double-blinded study, we assessed the efficacy of patient-controlled analgesia (PCA) for continuous interscalene analgesia after open shoulder surgery. Sixty patients were divided into three groups of 20. During a 48-h period, they received, via an interscalene catheter, a continuous infusion of 0.125% bupivacaine with sufentanil 0.1 microg/mL and clonidine 1 microg/mL at 10 mL /h in Group 1; a continuous infusion of the same solution at 5 mL/h plus PCA boluses (2.5 mL/30 min) in Group 2; and only PCA boluses (5 mL/30 min) of the same solution in Group 3. Pain scores, sensory block, supplemental analgesia, bupivacaine consumption, side effects, and satisfaction scores were recorded. At 24 and 48 h, sensory block was more frequent and pain control was significantly better in Groups 1 and 2 than in Group 3 (P < 0.001). In Group 3, larger doses of paracetamol were required. Bupivacaine consumption was significantly less in Groups 2 and 3 than in Group 1 (P < 0.001). Satisfaction was significantly higher in Groups 1 and 2 than in Group 3 (P < 0.01). Side effects were comparable in the three groups. We conclude that continuous interscalene analgesia requires a background infusion after open shoulder surgery. Because it reduces the local anesthetic consumption and allows the patients to rapidly reinforce the block shortly before physiotherapy, a basal infusion rate of 5 mL/h combined with PCA boluses (2.5 mL/ 30 min) is the recommended technique.
In this study, we demonstrated that continuous interscalene analgesia requires a background infusion to provide efficient pain relief after open shoulder surgery. A basal infusion of 5 mL/h combined with patient-controlled analgesia boluses (2.5 mL/30 min) seems to be the most appropriate technique.
在这项前瞻性、随机、双盲研究中,我们评估了患者自控镇痛(PCA)用于开放性肩部手术后持续肌间沟镇痛的疗效。60例患者被分为3组,每组20例。在48小时期间,第1组通过肌间沟导管以10 mL/h的速度持续输注含0.1微克/毫升舒芬太尼和1微克/毫升可乐定的0.125%布比卡因溶液;第2组以5 mL/h的速度持续输注相同溶液并加用PCA推注(2.5 mL/30分钟);第3组仅给予相同溶液的PCA推注(5 mL/30分钟)。记录疼痛评分、感觉阻滞、辅助镇痛、布比卡因用量、副作用和满意度评分。在24小时和48小时时,第1组和第2组的感觉阻滞更频繁,疼痛控制明显优于第3组(P<0.001)。第3组需要更大剂量的对乙酰氨基酚。第2组和第3组的布比卡因用量明显少于第1组(P<0.001)。第1组和第2组的满意度明显高于第3组(P<0.01)。三组的副作用相当。我们得出结论,开放性肩部手术后持续肌间沟镇痛需要背景输注。由于其可减少局部麻醉药用量,并使患者在物理治疗前不久能迅速加强阻滞,推荐采用5 mL/h的基础输注速率联合PCA推注(2.5 mL/30分钟)的技术。
在本研究中,我们证明开放性肩部手术后持续肌间沟镇痛需要背景输注以提供有效的疼痛缓解。5 mL/h的基础输注联合患者自控镇痛推注(2.5 mL/30分钟)似乎是最合适的技术。